D-tyrosyl-glycine | 76172-87-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-tyrosyl-glycine
• 英文别名: 2-[[(2R)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]acetate
• CAS: 76172-87-7
• 化学式: C₁₁H₁₄N₂O₄
• 分子量: 238.243
• InChiKey: HPYDSVWYXXKHRD-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  D-tyrosyl-glycine 、 以 水 为溶剂， 以73%的产率得到
  参考文献：
  名称：

  Synthesis and structure of peptide–copper(II)–isocytosine ternary complexes

  摘要：

  Two ternary complexes [Cu(ala-gly)(isocyt)(H2O)]-H2O (1) and [Cu(L-tyr-gly) (isocyt)].3H(2)O (2) have been prepared and characterised by X-ray diffraction, optical, ESR and IR spectral data. Both compounds exist as slightly distorted square-planar complexes, with the four co-ordination sites occupied by the tridentate peptidic dianion [oxygen carboxylic O(7), nitrogen amidic N(13) and nitrogen aminic N(10)] and the N(3) of the pyrimidine base. In complex 1, obtained as a racemic compound, an additional weak axial interaction exists between the oxygen of a water molecule OW1 and the copper atom [Cu-OW1 distance 2.50 Angstrom]. Spectroscopic data are in accordance with the crystal structures. The isocytosine ligand is approximately orthogonal to the Cu-peptide moiety independently of the nature of the lateral chain. This disposition of the nucleobase contrasts with the coplanarity of the previously described Cu(II)-glygly-creatinine complex. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(02)01010-0

文献信息

• Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor
  申请人：——

  公开号：US20030092608A1

  公开（公告）日：2003-05-15

  A pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of a malignant tumor, which comprises as the active ingredient a polysaccharide derivative comprising a polysaccharide having a carboxyl group bound to an active substance having an anti-tumor activity via an amino acid or a peptide consisting of 2 to 8 amino acids which are the same or different, or a salt thereof.

  一种用于抑制恶性肿瘤转移或防止其复发的药物组合物，其活性成分包括一种多糖衍生物，该多糖衍生物具有一个羧基，通过一个氨基酸或由 2 至 8 个相同或不同的氨基酸组成的肽与一种具有抗肿瘤活性的活性物质结合，或其盐。
• PHARMACEUTICAL COMPOSITIONS COMPRISING POLYSACCHARIDE CONJUGATES FOR INHIBITING THE METASTASIS OR PREVENTING THE RECURRENCE OF MALIGNANT TUMOR
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1418947A1

  公开（公告）日：2004-05-19
• [EN] PHARMACEUTICAL COMPOSITIONS COMPRISING POLYSACCHARIDE CONJUGATES FOR INHIBITING THE METASTSIS OR PREVENTING THE RECURRENCE OF MALIGANT TUMOR<br/>[FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES CONJUGUES DE POLYSACCHARIDES PERMETTANT L'INHIBITION DES METASTASES OU LA PREVENTION DE LA RECURRENCE DES TUMEURS MALIGNES
  申请人：TANABE SEIYAKU CO

  公开号：WO2003015826A1

  公开（公告）日：2003-02-27

  A pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of a malignant tumor, which comprises as the active ingredient a polysaccharide derivative comprising a polysaccharide having a carboxyl group bound to an active substance having an anti-tumor activity via an amino acid or a peptide consisting of 2 to 8 amino acids which are the same or different, or a salt thereof. Preferred active substances are camptothecin derivatives.