5-Pyrimidinecarboxamide, 2-[(1-benzo[b]thien-2-ylcyclopropyl)amino]-N-hydroxy- | 1375466-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Pyrimidinecarboxamide, 2-[(1-benzo[b]thien-2-ylcyclopropyl)amino]-N-hydroxy-
• 英文别名: 2-[[1-(1-benzothiophen-2-yl)cyclopropyl]amino]-N-hydroxypyrimidine-5-carboxamide
• CAS: 1375466-19-5
• 化学式: C₁₆H₁₄N₄O₂S
• 分子量: 326.4
• InChiKey: ZKSVMCALLBTCSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Acetylon Pharmaceuticals, Inc.

  公开号：EP2640709B1

  公开（公告）日：2016-04-06
• PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Acetylon Pharmaceuticals

  公开号：US20140142104A1

  公开（公告）日：2014-05-22

  The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
• US9409890B2
  申请人：——

  公开号：US9409890B2

  公开（公告）日：2016-08-09
• [EN] PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS D'HYDROXYPYRIMIDINE AMIDE UTILISÉS COMME INHIBITEURS DE LA PROTÉINE DÉACÉTYLASE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ACETYLON PHARMACEUTICALS

  公开号：WO2012068109A2

  公开（公告）日：2012-05-24

  The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.