benzo[d][1,3]dioxole-5-carbaldehyde O-phenyl oxime | 1166839-39-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: benzo[d][1,3]dioxole-5-carbaldehyde O-phenyl oxime
• 英文别名: 1-(1,3-benzodioxol-5-yl)-N-phenoxymethanimine
• CAS: 1166839-39-9
• 化学式: C₁₄H₁₁NO₃
• 分子量: 241.246
• InChiKey: KMQPZWFFBMYSPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  40
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  胡椒醛肟 、 苯硼酸 在 吡啶 、 copper diacetate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 48.0h， 以56%的产率得到benzo[d][1,3]dioxole-5-carbaldehyde O-phenyl oxime
  参考文献：
  名称：

  Copper(II) Acetate–Mediated Cross-Coupling of Phenylboronic Acids with Aryloximes: Synthesis of O-Aryloximes

  摘要：

  A novel method for the synthesis of O-aryloxime is described. It consisted of the coupling reaction between phenylboronic acids and aryloximes in the presence of catalytic quantities of copper(II) acetate. This reaction takes place in the presence of pyridine under a mild condition (DCE, Rt, 24-36h) with moderate yield. It represents a good alternative to known methods for O-aryloxime synthesis.

  DOI：

  10.1080/00397910802590910

文献信息

• Copper(II) Acetate–Mediated Cross-Coupling of Phenylboronic Acids with Aryloximes: Synthesis of O-Aryloximes
  作者：Xing-Hua Feng、Guo-Zhen Zhang、Cheng-Qun Chen、Ming-Yu Yang、Xiao-Yun Xu、Guo-Sheng Huang

  DOI：10.1080/00397910802590910

  日期：2009.4.22

  A novel method for the synthesis of O-aryloxime is described. It consisted of the coupling reaction between phenylboronic acids and aryloximes in the presence of catalytic quantities of copper(II) acetate. This reaction takes place in the presence of pyridine under a mild condition (DCE, Rt, 24-36h) with moderate yield. It represents a good alternative to known methods for O-aryloxime synthesis.