5-(3,5-difluorophenyl)pyrazin-2-ylamine | 438585-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(3,5-difluorophenyl)pyrazin-2-ylamine
• 英文别名: 5-(3,5-Difluorophenyl)pyrazin-2-amine
• CAS: 438585-80-9
• 化学式: C₁₀H₇F₂N₃
• 分子量: 207.182
• InChiKey: DPWOZNVQVBJLOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cis-4-(2-oxooxazolidin-3-yl)cyclohexanecarboxylic acid 、 5-(3,5-difluorophenyl)pyrazin-2-ylamine 生成
  参考文献：
  名称：

  AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS

  摘要：

  本发明揭示了一系列神经肽Y Y5受体配体，因此可用于治疗与情绪、压力、注意力缺陷多动障碍、认知、压力和痴呆症有关的疾病。

  公开号：

  US20120101078A1

文献信息

• BIOLOGICALLY ACTIVE AMIDES
  申请人：Peterson John Matthew

  公开号：US20110230497A1

  公开（公告）日：2011-09-22

  The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from certain disorders which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from certain disorders.

  本发明涉及生物活性酰胺，其是NPY Y5受体的配体。该发明还提供了一种制药组合物，包括本发明化合物的治疗有效量和药学可接受载体。本发明还提供了治疗患有某些疾病的受试者的方法，包括向受试者投予本发明化合物的量。此外，本发明还提供了一种利用本发明化合物制造治疗患有某些疾病的受试者的药物的用途。
• cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists
  作者：James Ford Burns、Bin Chen、Chien-An Chen、Dario Doller、Eman Edelmenky、Yu Jiang、John M. Peterson、Michael Sabio、Jessie Weiss、Andrew D. White、Lingyun Wu、Rajinder Bhardwaj、Gamini Chandrasena、Noel J. Boyle、Xinyan Huang

  DOI：10.1016/j.bmcl.2014.02.023

  日期：2014.3

  The NPY5 receptor binding and pharmacokinetic properties of a novel series of cis-1-oxo-heterocyclyl-4-amido-cyclohexane derivatives are described. (C) 2014 Elsevier Ltd. All rights reserved.
• HETEROARYL UREA NEUROPEPTIDE Y Y5 RECEPTOR ANTAGONISTS
  申请人：Schering Corporation

  公开号：EP1343503B1

  公开（公告）日：2008-11-12
• US7309704B2
  申请人：——

  公开号：US7309704B2

  公开（公告）日：2007-12-18
• [EN] BIOLOGICALLY ACTIVE AMIDES<br/>[FR] AMIDES BIOLOGIQUEMENT ACTIFS
  申请人：LUNDBECK & CO AS H

  公开号：WO2010053861A2

  公开（公告）日：2010-05-14

  The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from certain disorders which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from certain disorders.