<4-Methyl-benzyl>-ethyl-sulfon | 874506-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <4-Methyl-benzyl>-ethyl-sulfon
• 英文别名: ethyl-(4-methyl-benzyl)-sulfone；Aethyl-(4-methyl-benzyl)-sulfon；1-(Ethylsulfonylmethyl)-4-methylbenzene
• CAS: 874506-32-8
• 化学式: C₁₀H₁₄O₂S
• 分子量: 198.286
• InChiKey: NBVGKNZJAFFYIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  <4-Methyl-benzyl>-ethyl-sulfon 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 生成 ω-Brom-ω'-ethylsulfonyl-p-xylol
  参考文献：
  名称：

  674.消除—加法。第二部分 ωω'-二烷基磺酰基二甲苯反应中的醌类中间体

  摘要：

  DOI：

  10.1039/jr9620003425
• 作为产物：
  描述：

  Ethyl 4-methylbenzyl sulfide 在 双氧水 、 溶剂黄146 作用下， 生成 <4-Methyl-benzyl>-ethyl-sulfon
  参考文献：
  名称：

  Alkyl Phenyl-(2-pyridyl)-methyl Sulfones. Sulfonium Salts as Alkylating Agents

  摘要：

  DOI：

  10.1021/ja01149a059

文献信息

• [EN] P300 INHIBITORS AND USE THEREOF IN MEDICINE<br/>[FR] INHIBITEURS DE P300 ET LEUR UTILISATION EN MÉDECINE<br/>[ZH] P300抑制剂及其在医药上的应用
  申请人：BETTA PHARMACEUTICALS CO LTD

  公开号：WO2022095989A1

  公开（公告）日：2022-05-12

  涉及一种化合物，其具有癌症治疗活性,还涉及这些化合物的制备方法以及包含其的药物组合物。
• Novel Compounds and Compositions as Cathepsin Inhibitors
  申请人：Patterson W. John

  公开号：US20070232654A1

  公开（公告）日：2007-10-04

  The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及新型选择性卡特普西林S抑制剂，其药学上可接受的盐和N-氧化物，以及它们作为治疗剂的用途和制备方法。
• Novel compounds and compositions as cathepsin inhibitors
  申请人：Graupe Michael

  公开号：US20070049594A1

  公开（公告）日：2007-03-01

  The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及一种新型选择性卡普林S抑制剂，其药物可接受的盐和N-氧化物，以及它们作为治疗剂的用途和制备方法。
• NOVEL AZOLE COMPOUND
  申请人：YAMAMOTO Takashi

  公开号：US20130041000A1

  公开（公告）日：2013-02-14

  Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.

  公式I所代表的氮唑化合物，其中环A是异噁唑等，R1是取代或未取代的芳基基团等，R2是氢原子等，R3是取代或未取代的烷基基团等，以及其药学上可接受的盐，能够抑制溶血磷脂酸（LPA）的生理活性，可用于预防或治疗需要抑制LPA生理活性的疾病，例如涉及LPA受体的疾病。
• Synthesis of cyclophanes for a self-assembly reaction
  申请人：University of Oregon

  公开号：US10344005B2

  公开（公告）日：2019-07-09

  Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.

  本文公开了一种制备环烷的新方法，该方法包括将包含两个或两个以上硫醇基团的连接分子与金属盐和氧化剂接触，形成二硫化环烷。然后将二硫化环烷脱硫，形成包含硫醚桥的硫代环烷。这种硫代环烷还可以进一步脱硫，形成不饱和烃环烷，然后再还原形成饱和烃环烷。各种环烷可合成为环状，如二聚体、三聚体或四聚体等，也可合成为四面体或更大的结构。同时公开的还有通过公开方法形成的新型环烷。