2-(4-methylphenyl)-6-[2-(4-methylphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazole | 894733-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(4-methylphenyl)-6-[2-(4-methylphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazole
• CAS: 894733-92-7
• 化学式: C₂₈H₂₂N₄
• 分子量: 414.509
• InChiKey: CDGVTULYNISERM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲基苯甲酰氯 、 3,3'-二氨基联苯胺 在 potassium fluoride on basic alumina 、 magnesium sulfate 作用下， 以 乙腈 为溶剂， 反应 1.5h， 以70%的产率得到2-(4-methylphenyl)-6-[2-(4-methylphenyl)-3H-benzimidazol-5-yl]-1H-benzimidazole
  参考文献：
  名称：

  KF / Al 2 O 3：室温下一锅合成苯并咪唑和双苯并咪唑的高效固体多相碱催化剂

  摘要：

  摘要KF / Al 2 O 3是一种有效的固体非均相碱催化剂，可用于由1,2-苯二胺或3,3'-二氨基联苯胺和酰氯一锅法合成2-取代的苯并咪唑和2,2'-二取代的双-苯并咪唑，酸酐和酯在室温下。 图形概要

  DOI：

  10.1007/s00706-011-0647-7

文献信息

• Synthesis of new class of non-sulfonamide bis-benzimidazoles as antitumor agents by inhibiting carbonic anhydrase-IX enzyme
  作者：Shakeel Ahmad Khan、Zarbad Shah、Syed Raza Shah、Majid Khan、Sobia Ahsan Halim、Ajmal Khan、Javid Hussain、Magda H. Abdellattif、Bashir Ahmad、Ahmed Al-Harrasi

  DOI：10.1016/j.ijbiomac.2023.128259

  日期：2024.1

  the tumor growth of epithelial cells in breast and lung cancer by acidifying tumor microenvironment, therefore, inhibition of this target is important in antitumor therapy. We have synthesized bis-benzimidazole derivatives (1–25) by using 3,3′-diaminobenzidine and various aromatic aldehydes and characterized by various spectroscopic methods (UV/Visible, 1HNMR, 13CNMR, and mass spectrometry). Their inhibitory

  在几种类型的癌症中，碳酸酐酶-IX（CA-IX）酶的表达高于正常水平，最终通过酸化肿瘤微环境，在乳腺癌和肺癌上皮细胞的肿瘤生长中发挥关键作用，因此，抑制该靶点在抗肿瘤治疗中很重要。我们使用 3,3'-二氨基联苯胺和各种芳香醛合成了双苯并咪唑衍生物 ( 1–25 )，并通过各种光谱方法（紫外/可见光、 1 HNMR、 13 CNMR 和质谱）进行表征。在体外评估了它们对人 CA-IX ( h CA-IX) 的抑制潜力，其中几种合成的衍生物显示出对h CA-IX 的有效抑制作用（IC 50值在 5.23 ± 1.05 至 40.10 ± 1.78 μM 范围内）和化合物3-5、7-8、13-16、21和23显示出比标准药物“乙酰唑胺”更优异的活性（IC 50 = 18.24 ± 1.43 μM）。此外，所有这些化合物对人成纤维细胞系（BJ 细胞系）均没有毒性。此外，进行分子对接以预测它们在CA
• Heat resistant polyimide film and preparation method thereof
  申请人：Institute of Petroleum Chemistry, Heilongjiang Academy of Sciences

  公开号：US11028226B2

  公开（公告）日：2021-06-08

  A high temperature resistant polyimide film and its preparation method. The present invention relates to a polyimide film and its preparation method and solves the problems of honeycomb's and skin panel's core adhesive—polyimide film with insufficient heat resistance, no climbing of bonding core structure and adhesive fillet formation. The high temperature resistant polyimide film is made by polyimide solution, inorganic filler modifier and interface coupling agent by the steps of: under specific temperature and stirring conditions, adding inorganic filler modifier and interface coupling agent to polyimide solution, stirring to obtain the adhesive agent; filtering and degassing the adhesive agent, casting to a stainless steel drum with carrier cloth and release paper to obtain a self-supporting film; then heating and annealing to obtain the final polyimide film. The present invention is applied to high temperature resistant polyimide film and its preparation method.

  一种耐高温聚酰亚胺薄膜及其制备方法。本发明涉及一种聚酰亚胺薄膜及其制备方法，解决了蜂窝板和蒙皮板芯材粘接聚酰亚胺薄膜耐高温性能不足、粘接芯材结构不爬升和粘接起丝的问题。本发明的耐高温聚酰亚胺薄膜由聚酰亚胺溶液、无机填料改性剂和界面偶联剂制成，其制备步骤为：在特定温度和搅拌条件下，向聚酰亚胺溶液中加入无机填料改性剂和界面偶联剂，搅拌均匀得到粘接剂；将粘接剂过滤脱气，浇注到带有载布和离型纸的不锈钢桶中，得到自承膜；然后加热退火，得到最终的聚酰亚胺薄膜。本发明适用于耐高温聚酰亚胺薄膜及其制备方法。
• [EN] HIGH-TEMPERATURE-RESISTANT POLYIMIDE ADHESIVE FILM AND PREPARATION METHOD THEREFOR<br/>[FR] PELLICULE ADHÉSIVE POLYIMIDE RÉSISTANT AUX HAUTES TEMPÉRATURES ET SON PROCÉDÉ DE PRÉPARATION<br/>[ZH] 一种耐高温聚酰亚胺胶膜及其制备方法
  申请人：INST OF PETROLEUM CHEMISTRY HEILONGJIANG ACADEMY OF SCIENCES

  公开号：WO2019075786A1

  公开（公告）日：2019-04-25

  一种耐高温聚酰亚胺胶膜及其制备方法，解决现有的粘接蜂窝和蒙皮壁板的板芯胶-聚酰亚胺胶膜存在耐热性不足，板芯结构粘接无爬升和胶瘤的问题。由聚酰亚胺溶液、无机填料改性剂及界面偶联剂制成。制备方法：在一定温度及搅拌条件下，将无机填料改性剂及界面偶联剂加入到聚酰亚胺溶液中，搅拌，得到胶粘剂；将胶粘剂过滤并脱气，流延到负载有载体布和隔离纸的不锈钢制转鼓上，得到具有自支撑性的膜，然后加热并退火，得到耐高温聚酰亚胺胶膜。
• POLY(ARYL ETHER) WITH PENDENT SULFONIC ACID PHENYL GROUPS
  申请人：National Research Council of Canada

  公开号：EP2046862B1

  公开（公告）日：2013-02-13
• METHOD FOR PRODUCING A PROTON-CONDUCTING, STRUCTURED ELECTROLYTE MEMBRANE
  申请人：ERDLER Gilbert

  公开号：US20110217659A1

  公开（公告）日：2011-09-08

  In a method for producing a proton-conductive, structured electrolyte membrane, particularly for a fuel cell, a coating, which comprises at least one ion-conductive cross-linking component having at least one acid group and at least one photoactive substances interacting therewith, is applied onto a solid body surface. The coating is optically masked in that at least one region of the coating, in which the electrolyte membrane is supposed to be, is exposed such that the cross-linking component cross-links with the photoactive substances to form a polymer and/or copolymer network adhering to the solid body surface. At least one unexposed region of the coating is removed in order to structure the electrolyte membrane.