(1R)-1-(6-bromo-1H-benzimidazol-2-yl)-3-methylbutan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (1R)-1-(6-bromo-1H-benzimidazol-2-yl)-3-methylbutan-1-amine
• 化学式: C₁₂H₁₆BrN₃
• 分子量: 282.18
• InChiKey: WKHWVBBIIZLYIH-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] HETEROCYCLIC KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE HÉTÉROCYCLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016022312A1

  公开（公告）日：2016-02-11

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开内容通常涉及能够抑制AAK1（适配器相关激酶1）的化合物、包含该化合物的组合物以及抑制AAK1的方法。
• Heterocyclic kinase inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10035777B2

  公开（公告）日：2018-07-31

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

  本公开内容一般涉及可抑制 AAK1（适配体相关激酶 1）的化合物、包含此类化合物的组合物以及抑制 AAK1 的方法。
• HETEROCYCLIC KINASE INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170260145A1

  公开（公告）日：2017-09-14

  The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.