Apoatropine hydrochloride | 5978-81-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Apoatropine hydrochloride
• 英文别名: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-phenylprop-2-enoate;hydrochloride
• CAS: 5978-81-4
• 化学式: C17H22ClNO2
• 分子量: 307.8
• InChiKey: RALAARQREFCZJO-JXMYBXCISA-N

物化性质

• 熔点：
  239℃
• 溶解度：
  可溶于氯仿（轻微）、DMSO（轻微、加热）、甲醇（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Dosage form for time-varying patterns of drug delivery
  申请人：——

  公开号：US20030125714A1

  公开（公告）日：2003-07-03

  The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.

  本发明提供了一种多重释放口服给药系统，该系统在给受试者用药后的初始无药释放间隔期和释放另一剂量药物前的第二个无药释放期后开始释放药物。该系统有：（1）封闭在半透膜内的内部隔室；（2）在半透膜外部的药物涂层，由微孔膜包围，微孔膜可渗透液体和药物。药物涂层在初始无药物释放间隔期后释放。内室药物在无药物内室提供的第二个无药物释放间隔期后释放。
• Dosage Form for Time-Varying Patterns of Drug Delivery
  申请人：Edgren Emil David

  公开号：US20070207204A1

  公开（公告）日：2007-09-06

  The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.