5-(2-chloro-phenyl)-pyrimidine-2,4-diyldiamine | 130801-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(2-chloro-phenyl)-pyrimidine-2,4-diyldiamine
• 英文别名: 5-(2-Chlor-phenyl)-pyrimidin-2,4-diyldiamin；5-(2-Chlorophenyl)pyrimidine-2,4-diamine
• CAS: 130801-37-5
• 化学式: C₁₀H₉ClN₄
• 分子量: 220.661
• InChiKey: BVWVBAFKSRBVDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 2-(2-Chlorophenyl)-2-formylacetonitrile 在 乙醚 作用下， 生成 5-(2-chloro-phenyl)-pyrimidine-2,4-diyldiamine
  参考文献：
  名称：

  2,4-Diaminopyrimidines as Antimalarials. III. 5-Aryl Derivatives

  摘要：

  DOI：

  10.1021/ja01152a060

文献信息

• Pharmacologically active CNS compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0372934A2

  公开（公告）日：1990-06-13

  A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.

  本研究公开了一类取代苯基嘧啶化合物，它们是兴奋性氨基酸谷氨酸的强效抑制剂。此类化合物可用于治疗或预防一系列中枢神经系统疾病，包括脑缺血损伤和癫痫。
• Substituted phenylpyrimidine derivatives, useful in the treatment of prevention of CNS disorders
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0715851A2

  公开（公告）日：1996-06-12

  A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.

  本研究公开了一类取代苯基嘧啶化合物，它们是兴奋性氨基酸谷氨酸的强效抑制剂。 此类化合物可用于治疗或预防一系列中枢神经系统疾病，包括脑缺血损伤和癫痫。
• Substituted phenylpyrimidine derivatives, useful in the treatment or prevention of CNS disorders
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0713703A2

  公开（公告）日：1996-05-29

  A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy.

  本研究公开了一类取代苯基嘧啶化合物，它们是兴奋性氨基酸谷氨酸的强效抑制剂。此类化合物可用于治疗或预防一系列中枢神经系统疾病，包括脑缺血损伤和癫痫。
• HETEROCYCLIC DERIVATIVE AND MEDICINE
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0781766A1

  公开（公告）日：1997-07-02

  A pharmaceutical composition comprising a compound of the following general formula [I] or its salt. wherein R1 represents aryl or a heteroaromatic group. R2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl. R3 and R4 independently represent hydrogen or alkyl or R3 and R4 taken together with the adjacent N atom represent a 5- through 7-membered cyclic amino group. A represents C2-10 alkylene. W represents O, S, or (CH)n (where CH may be substituted by alkyl; n is an integer of 0, 1 or 2). X, Y, and Z may be the same or different and each represents CH (which may be substituted by alkyl), or N. Provided, however, that the case in which X, Y, and Z concurrently represent CH is excluded. The compound of the invention has excellent neuronal death inhibitory activity and is useful as a therapeutic drug for cerebrovascular diseases.

  一种药物组合物，包含下式通式[I]的化合物或其盐。 其中 R1 代表芳基或杂芳基。 R2 代表氢、烷基、烯基、环烷基、环烷基烷基、羟基烷基、卤代烷基、烷氧基、烷硫基、氨基、单烷基氨基、二烷基氨基或苯基。R3 和 R4 独立地代表氢或烷基，或 R3 和 R4 与相邻的 N 原子一起代表 5 至 7 元环状氨基。A 代表 C2-10 亚烷基。W 代表 O、S 或 (CH)n（其中 CH 可被烷基取代；n 为 0、1 或 2 的整数）。X、Y 和 Z 可以相同或不同，各自代表 CH（可被烷基取代）或 N，但不包括 X、Y 和 Z 同时代表 CH 的情况。 本发明化合物具有优异的神经元死亡抑制活性，可作为脑血管疾病的治疗药物。
• Piperazinyl-substituted phenyl pyrimidine derivatives useful in the treatment or prevention of disorders of the central nervous system
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP1325916A1

  公开（公告）日：2003-07-09

  A class of substituted phenylpyrimidine compounds are disclosed which are potent inhibitors of the excitatory amino acid, glutamate. Such compounds are useful in the treatment or prevention of a range of CNS disorders including cerebral ischaemic damage and epilepsy. wherein: R1 is piperazinyl; R2 is amino; R3 is hydrogen, C1-C6 alkyl, trifluoromethyl, C1-C6 alkoxy, C1-C6 alkylthio, (C1-C6 alkyl)thio(C1-C6 alkyl), di[(C1-C6 alkyl)oxy] (C1-C6 alkyl), or CH2X wherein X is C1-C6 alkoxy, phenoxy or benzyloxy; each of R4, R5, R7 and R8 is the same or different and is selected from hydrogen and halo, or R4 and R5 together denote -CH=CH-CH=CH- in which case both R7 and R8 are hydrogen; R6 is hydrogen, halo, nitro or amino; and pharmaceutically acceptable acid addition salts thereof.

  本研究公开了一类取代苯基嘧啶化合物，它们是兴奋性氨基酸谷氨酸的强效抑制剂。此类化合物可用于治疗或预防一系列中枢神经系统疾病，包括脑缺血损伤和癫痫。 其中 R1 是哌嗪基 R2 是氨基 R3 是氢、C1-C6 烷基、三氟甲基、C1-C6 烷氧基、C1-C6 烷硫基、(C1-C6 烷基)硫(C1-C6 烷基)、二[(C1-C6 烷基)氧基](C1-C6 烷基)或 CH2X，其中 X 是 C1-C6 烷氧基、苯氧基或苄氧基； R4、R5、R7 和 R8 各自相同或不同，且选自氢和卤素，或 R4 和 R5 共同表示-CH=CH-CH=CH-，在这种情况下，R7 和 R8 都是氢； R6 是氢、卤素、硝基或氨基； 及其药学上可接受的酸加成盐。