Methyl 2-chloro-3-(6-phenylthio-3-pyridyl)-propionate | 107756-06-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: Methyl 2-chloro-3-(6-phenylthio-3-pyridyl)-propionate
• 英文别名: Methyl 2-chloro-3-(6-phenylthio-3-pyridyl)propionate；methyl 2-chloro-3-(6-phenylsulfanylpyridin-3-yl)propanoate
• CAS: 107756-06-9
• 化学式: C₁₅H₁₄ClNO₂S
• 分子量: 307.801
• InChiKey: UQUKPOGHBGXXHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 2-chloro-3-(6-phenylthio-3-pyridyl)-propionate 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 methyl 2-chloro-3-(6-phenylsulfinyl-3-pyridyl)propionate
  参考文献：
  名称：

  Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same

  摘要：

  公开号：

  EP0210782B1

文献信息

• .omega.-(3-pyridyl)alkenamide derivatives and anti-allergenic
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：US04778796A1

  公开（公告）日：1988-10-18

  Compounds of the formula: ##STR1## wherein X is alkylene or --(CR.sub.6 .dbd.CR.sub.7).sub.r -- wherein R.sub.6 is H, alkyl or phenyl, R.sub.7 is H, alkyl, cyano or phenyl, and r is 1 or 2; A is alkylene or alkylene interrupted by at least one double bond; R.sub.1 is H, halogen, alkyl, alkoxy, alkylthio, cycloalkyloxy, cycloalkylthio, alkoxycarbonyl, carboxy, phenyl, phenoxy, phenylthio, 3-pyridyloxy or 3-pyridylthio; R.sub.2 is H, hydroxy, alkanoyloxy or alkoxycarbonyloxy, or adjacent R.sub.1 and R.sub.2 may combine to form tetramethylene or --CH.sub.2 OCR.sub.8 R.sub.9 O-- (R.sub.8 and R.sub.9 are alkyl); R.sub.3 is H, alkyl or hydroxyalkyl; R.sub.4 is H or alkyl; R.sub.5 is phenyl, heteroaryl or --(CH.sub.2).sub.m --CHR.sub.10 R.sub.11 (R.sub.10 is H or phenyl, R.sub.11 is phenyl or pyridyl and m is 0 to 2); p is 0 or 1; and q is 2 or 3; the phenyl group or moiety being optionally substituted, and a salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. Said compounds and salts thereof show excellent antiallergic activity mainly through 5-lipoxygenase inhibiting activity, antihistamine activity and/or inhibitory activity against chemical mediator release and useful for treatment of allergic diseases.

  该公式化合物为：##STR1## 其中X为烷基或--(CR.sub.6.dbd.CR.sub.7).sub.r --，其中R.sub.6为H、烷基或苯基，R.sub.7为H、烷基、氰基或苯基，r为1或2；A为烷基或至少有一个双键的烷基；R.sub.1为H、卤素、烷基、烷氧基、烷硫基、环烷氧基、环烷硫基、烷氧羰基、羧基、苯基、苯氧基、苯硫基、3-吡啶氧基或3-吡啶硫基；R.sub.2为H、羟基、烷酰氧基或烷氧羰酰氧基，或相邻的R.sub.1和R.sub.2可以结合形成四亚甲基或--CH.sub.2 OCR.sub.8 R.sub.9 O--（其中R.sub.8和R.sub.9为烷基）；R.sub.3为H、烷基或羟基烷基；R.sub.4为H或烷基；R.sub.5为苯基、杂环芳基或--(CH.sub.2).sub.m --CHR.sub.10 R.sub.11（其中R.sub.10为H或苯基，R.sub.11为苯基或吡啶基，m为0到2）；p为0或1；q为2或3；苯基或基团可选择性地被取代；以及其盐、制备方法和含有它的药物组成物。所述化合物及其盐主要通过5-脂氧酶抑制活性、抗组胺活性和/或化学介质释放抑制活性表现出优异的抗过敏活性，并用于治疗过敏性疾病。
• US4778796A
  申请人：——

  公开号：US4778796A

  公开（公告）日：1988-10-18
• Pyridine compounds, process for the preparation thereof and pharmaceutical composition containing the same
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：EP0210782B1

  公开（公告）日：1991-04-17