2,6-Dimethyl-3,4-diphenyl-pyrazolo[3,4-d]pyridazin-7-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,6-Dimethyl-3,4-diphenyl-pyrazolo[3,4-d]pyridazin-7-one
• 英文别名: 2,6-dimethyl-3,4-diphenylpyrazolo[3,4-d]pyridazin-7-one
• 化学式: C₁₉H₁₆N₄O
• 分子量: 316.362
• InChiKey: NQPCMZWIPSPZFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-benzoyl-5-phenyl-furan-2,3-dione 以 xylene 、 苯 为溶剂， 反应 5.0h， 生成 2,6-Dimethyl-3,4-diphenyl-pyrazolo[3,4-d]pyridazin-7-one
  参考文献：
  名称：

  Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives

  摘要：

  Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two new 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to < 0.0024 mg ml(-1). (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.12.001

文献信息

• Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives
  作者：Esvet Akbas、Ismet Berber

  DOI：10.1016/j.ejmech.2004.12.001

  日期：2005.4

  Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two new 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to < 0.0024 mg ml(-1). (c) 2005 Elsevier SAS. All rights reserved.