4,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one | 76806-90-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
• 英文别名: 4,5,9-trimethylfuro[3,2-g]chromen-7-one
• CAS: 76806-90-1
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.24
• InChiKey: CVYDCMMGOIGZFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• DIPYRIDINIUM DERIVATIVES
  申请人：Stewart John Charles Marshall

  公开号：US20140066449A1

  公开（公告）日：2014-03-06

  Compounds of Formula (I): α-x-β (I) and pharmaceutically acceptable salts and solvates thereof, wherein α, x, and β have the meanings as indicated in the specification, are useful for treating a disease or disorder characterised by pathologically proliferating cells, particularly cancer. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  式(I)的化合物：α-x-β(I)及其药学上可接受的盐和溶剂，其中α、x和β的含义如规范中所示，可用于治疗由病理性增殖细胞特征的疾病或紊乱，特别是癌症。还描述了含有这些化合物的药物组合物和制备这些化合物的方法。
• DNA labeling reagents, acridinium-9-carboxamide derivatives and process of preparing DNA labeling compounds
  申请人：AsiaGEN Corporation

  公开号：US20040219538A1

  公开（公告）日：2004-11-04

  The present invention relates to DNA labeling reagents comprising a furocoumarin derivative and a detectable group with or without bound via a binding enhancer, and acridinium-9-carboxamide derivatives for use as chemiluminescent labels. The present invention also relates to a process of preparing DNA labeling compound.

  本发明涉及包括呋喃香豆素衍生物和可检测基团的DNA标记试剂，可以通过结合增强剂结合或不结合，以及用作化学发光标记的吖啶-9-羧酰胺衍生物。本发明还涉及一种制备DNA标记化合物的方法。
• Peptides
  申请人：HOX THERAPEUTICS LIMITED

  公开号：US10494412B2

  公开（公告）日：2019-12-03

  The present invention relates to novel peptides, which impair PBX-dependent regulation of gene transcription and thus have utility in the treatment or prevention of disorders in which aberrant cell division occurs. In particular, the invention provides a peptide comprising the amino acid sequence (I): Y1X1X2KWX3X4X5X6X7Y2 (I) wherein the sequence X1 to X7 is an amino acid sequence comprising at least 7 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X1 is selected from W, T, PE, KQI, W, PQT, H, R1 and absent; X2 is an amino acid with an aromatic side chain or cysteine; X3 is a hydrophobic amino acid X4 is an amino acid with a charged side chain; X5 is an amino acid with a basic side chain; X6 is an amino acid or absent; X7 is one or more amino acids or absent; and Y1 and Y2 are each either absent or a peptide comprising a cationic polymer of basic amino acids, provided that at least one of Y1 and Y2 is present.

  本发明涉及新型多肽，它能损害依赖于 PBX 的基因转录调控，因此可用于治疗或预防细胞分裂异常的疾病。特别是，本发明提供了一种包含氨基酸序列（I）的多肽：Y1X1X2KWX3X4X5X6X7Y2 (I) 其中序列 X1 至 X7 是由至少 7 个氨基酸组成的氨基酸序列，可任选在本文定义的 9 个氨基酸位置中的一个或多个位置之间被一个或两个氨基酸残基打断；X1 选自 W、T、PE、KQI、W、PQT、H、R1 和无；X2 是具有芳香族侧链或半胱氨酸的氨基酸；X3 是疏水性氨基酸； X4 是带电荷侧链的氨基酸； X5 是带碱性侧链的氨基酸； X6 是一种氨基酸或不存在； X7 是一种或多种氨基酸或不存在； Y1 和 Y2 要么不存在，要么是由碱性氨基酸阳离子聚合物组成的肽，条件是至少存在 Y1 和 Y2 中的一种。
• Emulsified skin care composition containing salicylic acid, lanolin oil, and propylene glycol
  申请人：Alwyn Company, Inc.

  公开号：US20030157137A1

  公开（公告）日：2003-08-21

  A composition comprising an oil-in-water emulsion for skin care containing salicylic acid or another hydroxy acid, and propylene glycol to prevent formation of crystals of the hydroxy acid. The composition includes, as an emulsifier, at least one nonionic polyoxyethylene ether with a HLB of about 15 to about 17; in some embodiments, another nonionic polyoxyethylene ether with a HLB of 10 to 12 is also included. The composition also includes lanolin oil and a complex comprising Vitamin A and Vitamin D 3 . Other ingredients, such as a hydrophilic carbohydrate-containing polymer or a quaternary ammonium-containing polymer, can be included. Still other ingredients, such as preservatives, chelators, herbal extracts, allantoin and fragrance, can be included. Another aspect of the invention is a method of use of a composition according to the present invention in treating dermatological or systemic inflammatory conditions such as psoriasis, seborrheic dermatitis, and dandruff.

  一种水包油型护肤乳液组合物，含有水杨酸或另一种羟基酸，以及防止羟基酸结晶形成的丙二醇。该组合物包括至少一种 HLB 值约为 15 至 17 的非离子聚氧乙烯醚作为乳化剂；在某些实施方案中，还包括另一种 HLB 值为 10 至 12 的非离子聚氧乙烯醚。该组合物还包括羊毛脂油和由维生素 A 和维生素 D 组成的复合物 3 .还可包括其他成分，如亲水性含碳水化合物聚合物或含季铵聚合物。还可以加入其他成分，如防腐剂、螯合剂、草药提取物、尿囊素和香料。本发明的另一个方面是根据本发明的组合物用于治疗皮肤病或全身炎症，如牛皮癣、脂溢性皮炎和头皮屑的方法。
• Polymeric label molecules
  申请人：Zak Arieh S.

  公开号：US20060160098A1

  公开（公告）日：2006-07-20

  A method of constructing a highly labeled linear polymeric molecule for use in any desired application, and linear polymeric molecules of such structure. The polymeric molecule is a nucleic acid constructed from a large number of one or more types of monomeric oligonucleotide units that are attached together to form an extended strand. Within each polymer, at least one type of monomeric unit is provided which is bound to or designed to bind to a label moiety, providing a polymer with a large number of repeat sequences designed for labeling purposes, resulting in extremely effective signal carrying molecule of considerable versatility.

  一种用于任何所需应用的高标记线性聚合分子的构建方法，以及这种结构的线性聚合分子。聚合分子是一种核酸，由大量的一种或多种类型的单体寡核苷酸单元构建而成，这些单元连接在一起形成延伸的链。在每种聚合物中，至少有一种单体单元与标记分子结合或设计成与标记分子结合，从而提供了一种具有大量为标记目的而设计的重复序列的聚合物，形成了极为有效的信号携带分子，具有相当大的通用性。