Benzo(1,2)pyreno(4,5-b)oxirene | 52876-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: Benzo(1,2)pyreno(4,5-b)oxirene
• 英文别名: 18-oxahexacyclo[10.7.2.03,8.09,20.016,21.017,19]henicosa-1,3,5,7,9(20),10,12(21),13,15,17(19)-decaene
• CAS: 52876-26-3
• 化学式: C₂₀H₁₀O
• 分子量: 266.3
• InChiKey: UJOLLZJSDKJRJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Glutathione-S-transferase MU as a measure of drug resistance
  申请人：OXI-GENE, INC.

  公开号：EP0601238A1

  公开（公告）日：1994-06-15

  It has been discovered that by determining or measuring a person's glutathione-s-transferase (GST) mu activity one can determine or measure the individual's resistance to drugs, particularly to chemotherapeutic drugs. Approximately 50% of the human population exhibit substantially no GST mu activity, with the remaining 50% showing GST mu activity. This remaining 50% of the population accordingly, when treated with drugs, such as a chemotherapeutic drug for cancer therapy, show less effective response to the drug therapy than the other 50% of the population which have substantially no GST mu activity, since GST mu tends to deactivate drugs. Accordingly, a person having GST mu activity would exhibit drug resistance and would not benefit as much by or be as good a candidate for cancer chemotherapy as a person who has no GST mu activity.

  研究发现，通过确定或测量一个人的谷胱甘肽转移酶（GST）μ活性，可以确定或测量该人对药物，尤其是化疗药物的耐药性。人类中约有 50%的人基本上没有谷胱甘肽转移酶μ活性，其余 50%的人则显示出谷胱甘肽转移酶μ活性。由于 GST mu 有使药物失活的趋势，因此当使用药物（如用于癌症治疗的化疗药物）治疗时，这剩下的 50%的人群对药物治疗的有效反应要低于其他 50%的人群，因为其他 50%的人群基本上没有 GST mu 活性。因此，具有 GST mu 活性的人会表现出耐药性，不会像没有 GST mu 活性的人那样从癌症化疗中获益，也不会像没有 GST mu 活性的人那样适合接受癌症化疗。
• Liver cell clones for artifical liver and extracorporeal liver assist device
  申请人：JMS Co., Ltd.

  公开号：EP1063289A1

  公开（公告）日：2000-12-27

  Disclosed is a blood perfusion device or apparatus that is used for bioartificial liver support. Human hepatocyte lines established from normal regenerating liver tissue and modulated in toxin-challenging conditions are provided. These functional hepatocytes exhibit extraordinarily enhanced detoxification functions, which are characterised by the elevated glutathione content and glutathione S-transferase activity. A bioreactor is constructed with the functional hepatocytes for bioartificial liver support system, which includes perfusion inlets and perfusion outlets, a containment vessel, a centrifugal pump and macroporous microcarriers where the functional hepatocytes are grown.

  所公开的是一种用于生物人工肝支持的血液灌流装置或设备。提供了从正常再生肝组织中建立并在毒素挑战条件下调节的人类肝细胞系。这些功能性肝细胞的解毒功能异常增强，其特点是谷胱甘肽含量和谷胱甘肽 S 转移酶活性升高。该系统包括灌注入口和灌注出口、密闭容器、离心泵和生长功能肝细胞的大孔微载体。
• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• Synergistically active mixtures of alpha,omega-amino alcohol enantiomers, preparation thereof and use thereof in insect- and mite-repellent formulations
  申请人：KOCH Burkhard

  公开号：US20120083509A1

  公开（公告）日：2012-04-05

  What are described are insect- and mite-repellent compositions comprising at least 2 enantiomers selected from the group of 1-[(S)-sec-butyloxycarbonyl]-2-(S)-(2-hydroxyethyl)piperidine (referred to hereinafter as S,S), 1-[(R)-sec-butyloxycarbonyl]-2-(R)-(+)-(2-hydroxyethyl) piperidine (referred to hereinafter as R,R), 1-[(S)-sec-butoxycarbonyl]-2-(R)-(+)-(2-hydroxyethyl) piperidine (referred to hereinafter as S,R), 1-[(R)-sec-butyloxycarbonyl]-2-(S)-(+)-(2-hydroxyethyl) piperidine (referred to hereinafter as R,S), excluding the racemate mixture thereof, a process for preparation thereof and the use thereof in insect- and mite-repellent formulations.
• US5204241A
  申请人：——

  公开号：US5204241A

  公开（公告）日：1993-04-20