N-(5-(2,3-difluorophenyl)-1H-pyrazolo-[3,4-c]pyridazin-3-yl)-1-ethylpiperidine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(5-(2,3-difluorophenyl)-1H-pyrazolo-[3,4-c]pyridazin-3-yl)-1-ethylpiperidine-4-carboxamide
• 英文别名: N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyridazin-3-yl]-1-ethylpiperidine-4-carboxamide
• 化学式: C₁₉H₂₀F₂N₆O
• 分子量: 386.404
• InChiKey: XMLJBPQUTWBABY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  86.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 生成 N-(5-(2,3-difluorophenyl)-1H-pyrazolo-[3,4-c]pyridazin-3-yl)-1-ethylpiperidine-4-carboxamide
  参考文献：
  名称：

  5-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

  摘要：

  A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3). (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00134-3

文献信息

• VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS
  申请人：Frequency Therapeutics, Inc.

  公开号：US20220133740A1

  公开（公告）日：2022-05-05

  The present invention provides methods for treating diseases and disorders of the ear with valproic acid compounds and Wnt agonists. The present invention further provides kits for the same.
• 5-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
  作者：Jason Witherington、Vincent Bordas、Stephen L Garland、Deirdre M.B Hickey、Robert J Ife、John Liddle、Martin Saunders、David G Smith、Robert W Ward

  DOI：10.1016/s0960-894x(03)00134-3

  日期：2003.5

  A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3). (C) 2003 Elsevier Science Ltd. All rights reserved.