Benzyl benzenecarboperoxoate | 408529-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl benzenecarboperoxoate
• CAS: 408529-43-1
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.24
• InChiKey: JAHGTMJOPOCQIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] DISUBSTITUTED BENZAMIDE DERIVATIVES AS GLUCOKINASE (GK) ACTIVATORS<br/>[FR] DÉRIVÉS DE BENZAMIDES DISUBSTITUÉS ET UTILISÉS COMME ACTIVATEURS DE LA GLUCOKINASE (GK)
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2010150280A1

  公开（公告）日：2010-12-29

  The invention relates to disubstituted benzamide derivatives of the general Formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, metabolites and polymorphs. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds and to methods for treating type II diabetes using the compounds of the invention.

  该发明涉及一般式（I）的二取代苯甲酰胺衍生物，其药学上可接受的盐、药学上可接受的溶剂化合物、对映体、非对映体、前药、代谢物和多型体。该发明还涉及制备该发明化合物的方法、含有该化合物的药物组合物以及使用该发明化合物治疗2型糖尿病的方法。
• [EN] TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN GASTROPATHY<br/>[FR] DÉRIVÉS DE TRYPTAMINE, LEUR PRÉPARATION ET LEUR UTILISATION DANS UNE GASTROPATHIE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2012035406A1

  公开（公告）日：2012-03-22

  The present invention concerns the synthesis and evaluation of gastroprotective effect of different tryptamine derivatives. Tryptamine derivatives have been synthesized by formation of amide or ester with some known anti oxidant molecules. These derivatives show excellent antioxidant property in vitro. Among all the derivatives the compound SEGA (3 a), that was prepared by the combination of serotonin with gallic acid shows the greater antioxidant property than the other synthesized compounds both in vivo and in vitro. SEGA(3a) shows the gastroprotective effect against NSAIDs (indomethacin or diclofenac)-induced gastropathy in dose dependent manner and also accelerates the healing from injury. It prevents the NSAIDs-induced mitochondrial oxidative stress in vivo. This derivative prevents NSAID-induced mitochondrial oxidative stress-mediated apoptosis in vivo by preventing the activation of caspase 9 and caspase-3 and restores NSAIDs-mediated collapse of mitochondroial transmembrane potential and dehydrogenase activity. SEGA (3 a) plays an important role as an iron chelator as well as intra mitochondrial ROS scavenger. Thus, SEGA (3 a) is a potent antioxidant antiapototic molecule, which efficiently prevents NSAID-induced gastropathy and stress or alcohol -mediated gastric damage.

  本发明涉及合成和评估不同色胺衍生物的胃保护效果。色胺衍生物通过与一些已知的抗氧化分子形成酰胺或酯而被合成。这些衍生物在体外表现出优秀的抗氧化性能。在所有的衍生物中，通过将血清素与没食子酸结合制备的SEGA（3a）表现出比其他合成化合物更强的抗氧化性能，无论是在体内还是在体外。SEGA（3a）显示出对NSAIDs（消炎药，如消炎痛或双氯芬酸）诱导的胃病的剂量依赖性胃保护作用，并且加速受伤后的愈合。它可以预防NSAIDs诱导的体内线粒体氧化应激。该衍生物通过阻止caspase 9和caspase-3的活化，恢复NSAIDs介导的线粒体跨膜电位和脱氢酶活性的崩溃，从而预防NSAID诱导的线粒体氧化应激介导的凋亡。SEGA（3a）作为铁螯合剂和线粒体内ROS清除剂发挥重要作用。因此，SEGA（3a）是一种强效的抗氧化抗凋亡分子，有效预防NSAID诱导的胃病和压力或酒精介导的胃损伤。
• Wiring-connecting material and wiring-connected board production process using the same
  申请人：——

  公开号：US20040214979A1

  公开（公告）日：2004-10-28

  The present invention provides a wiring-connecting material comprising from 2 to 75 parts by weight of a polyurethane resin, from 30 to 60 parts by weight of a radical-polymerizable substance and from 0.1 to 30 parts by weight of a curing agent capable of generating a free radical upon heating, and a process for producing a wiring-connected board by using the wiring-connecting material. The wiring-connecting material of the present invention may preferably further contain a film-forming material and/or conductive particles.

  本发明提供了一种连接线材料，包括2至75重量份的聚氨酯树脂，30至60重量份的自由基聚合物质和0.1至30重量份的固化剂，该固化剂能在加热时产生自由基，以及使用该连接线材料制备连接线板的方法。本发明的连接线材料还可以包含成膜材料和/或导电粒子。
• CIRCUIT CONNECTING MATERIAL AND STRUCTURE FOR CONNECTING CIRCUIT MEMBER
  申请人：Tatsuzawa Takashi

  公开号：US20100277885A1

  公开（公告）日：2010-11-04

  A circuit connecting material which is situated between mutually opposing circuit electrodes and, upon pressing the mutually opposing circuit electrodes, electrically connects the electrodes in the pressing direction, the circuit connecting material having a laminated construction comprising an anisotropic conductive adhesive layer A with conductive particles 21 dispersed therein and an insulating adhesive layer B, wherein the adhesive force of the insulating adhesive layer B for glass substrates is greater than the adhesive force of the anisotropic conductive adhesive layer A for glass substrates.

  一种电路连接材料，该材料位于相互对立的电路电极之间，并在按压相互对立的电路电极时，在按压方向上电性连接电极，该电路连接材料具有层状结构，包括具有分散导电颗粒的各向异性导电粘合剂层A和绝缘粘合剂层B，其中绝缘粘合剂层B对玻璃基板的粘合力大于各向异性导电粘合剂层A对玻璃基板的粘合力。
• CIRCUIT-CONNECTING MATERIAL AND CIRCUIT TERMINAL CONNECTION STRUCTURE
  申请人：Arifuku Motohiro

  公开号：US20100277884A1

  公开（公告）日：2010-11-04

  The circuit-connecting material of the invention is a circuit-connecting material for connection between a first circuit member having a first circuit electrode formed on the main side of a first board, and a second circuit member having a second circuit electrode formed on the main side of a second board, with the first circuit electrode and the second circuit electrode laid facing each other, the circuit-connecting material comprising a film-forming material, a curing agent that generates free radicals upon heating, a radical-polymerizing substance, an isocyanate group-containing compound and a ketimine group-containing compound represented by the following general formula (I), wherein the isocyanate group-containing compound content is 0.1-5 parts by weight and the ketimine group-containing compound content is 0.1-5 parts by weight with respect to 100 parts by weight as the total of the film-forming material and radical-polymerizing substance. Wherein R represents an organic group, R 1 and R 2 each represent a C1-C4 monovalent aliphatic hydrocarbon group, and R 1 and R 2 may be linked together to form a cycloalkyl group.

  本发明的电路连接材料是用于连接第一电路成员和第二电路成员的电路连接材料，第一电路成员在第一板的主面上形成有第一电路电极，第二电路成员在第二板的主面上形成有第二电路电极，第一电路电极和第二电路电极相对放置，该电路连接材料包括一种成膜材料、一种加热后产生自由基的固化剂、一种自由基聚合物质、一种含有异氰酸酯基团的化合物和一种含有酮胺基团的化合物，该含有异氰酸酯基团的化合物含量为100份重量中的0.1-5份重量，该含有酮胺基团的化合物含量为100份重量中的0.1-5份重量，作为成膜材料和自由基聚合物质的总量。其中，R代表有机基团，R1和R2各代表C1-C4单价脂肪族碳氢基团，R1和R2可以连接形成环烷基团。