1,2-Difluoro-3,4-dinitrobenzene | 37583-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-Difluoro-3,4-dinitrobenzene
• CAS: 37583-41-8
• 化学式: C6H2F2N2O4
• 分子量: 204.09
• InChiKey: JXSSPZOCHGZWJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Compositions for Targeted Delivery of siRNA
  申请人：Rozema David B.

  公开号：US20110207799A1

  公开（公告）日：2011-08-25

  The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers.

  本发明涉及用于靶向递送RNA干扰（RNAi）多核苷酸至体内肝细胞的组合物。靶向RNAi多核苷酸与共靶向递送聚合物一起给予。递送聚合物提供膜穿透功能，用于将RNAi多核苷酸从细胞外运送到细胞内。可逆修饰为递送聚合物提供生理响应性。
• Charge reversal of polyion complexes and treatment of peripheral occlusive disease
  申请人：——

  公开号：US20030236214A1

  公开（公告）日：2003-12-25

  A process is described for the delivery of a therapeutic polynucleotide to a tissue suffering from or potentially suffering from ischemia. An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.

  描述了一种将治疗性多核苷酸递送到患有或潜在患有缺血的组织的过程。使用离子聚合物在“充电”（具有不同电荷的另一层）浓缩的多核苷酸复合物，以便将核酸递送到细胞中。形成的充电复合物可以具有适量的正或负电荷，使得形成的复合物具有所需的净电荷。
• Polynucleotide complex delivery
  申请人：——

  公开号：US20030166280A1

  公开（公告）日：2003-09-04

  Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic acid is expressed.

  揭示了一种在细胞中提供核酸表达的复合物。将多聚核苷酸和聚合物混合在一起形成复合物，其中复合物的ζ电位不是正的。然后将复合物传递到细胞中，其中核酸被表达。
• Intravascular delivery of non-viral nucleic acid
  申请人：——

  公开号：US20020137707A1

  公开（公告）日：2002-09-26

  Disclosed is a system for providing nucleic acid expression in a cell. A polynucleotide is inserted into a mammalian vasculature. The vessel permeability is increased and the polynucleotide is delivered to the cell where it enhances the endogenous properties of the cell.

  本系统揭示了一种在细胞中提供核酸表达的系统。将多核苷酸插入哺乳动物血管系统。增加血管通透性，将多核苷酸送达至细胞，从而增强细胞的内源性特性。
• Compound containing a labile disulfide bond
  申请人：Wolff A. Jon

  公开号：US20050020518A9

  公开（公告）日：2005-01-27

  A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.

  在生理条件下，含有不稳定二硫键和转导信号的不稳定二硫化合物。