2-hydroxy-2-(4-aminophenyl)propanoic acid hydrochloride | 1140066-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-2-(4-aminophenyl)propanoic acid hydrochloride
• 英文别名: 2-(4-Aminophenyl)-2-hydroxypropanoic acid
• CAS: 1140066-47-2
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: BBGRXNOJWKJKGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-[4-(1-cyano-1-hydroxyethyl)phenyl]-2,2,2-trifluoroacetamide 在 盐酸 、 水 作用下， 以 1,4-二氧六环 为溶剂， 以80%的产率得到2-hydroxy-2-(4-aminophenyl)propanoic acid hydrochloride
  参考文献：
  名称：

  通过HI水溶液处理从氰醇中方便地一锅制备2-芳基丙酸和芳酸

  摘要：

  已开发出一种新颖的一锅两步法，通过用氰化醇中的HI水溶液处理，可以合成高度取代的2-芳基丙酸和芳酸。α-羟基-2-芳基丙酸的氢解还原是该工艺的关键步骤，反应条件的优化确定了HI水溶液是氰醇还原性脱氧的合适和选择性试剂。合成路线描述了制备苯乙酸和苯丙酸衍生物的大型文库的通用有效策略。

  DOI：

  10.1016/j.tet.2009.01.005

文献信息

• Affinity chromatography matrix with built-in reaction indicator
  申请人：J.T. Baker Inc.

  公开号：EP0153763A2

  公开（公告）日：1985-09-04

  p-Nitrophenylester of succinoylaminopropyl silica gel is useflu as an affinity matrix for reacting with ligand for use in aifinity chromatography. The affinity matrix, upon reaction with a ligand, releases one molecule of p-nitrophenolate ion for every molecule of ligand that reacts and the solution turns yellow as the reaction occurs.

  琥珀酰氨基丙基硅胶的对硝基苯乙酯可用作亲和基质，与配体反应后用于亲和层析。亲和基质与配体反应后，每反应一分子配体，就会释放出一分子对硝基苯酚离子，反应发生时溶液会变成黄色。
• PROCESS FOR PRODUCING 1,2-ETHANEDIOL DERIVATIVES
  申请人：NITTO CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0816316A1

  公开（公告）日：1998-01-07

  A process for preparing a 1,2-ethanediol derivative in a high yield by reducing an α-hydroxy carboxylic acid ester derivative in a protic solvent or a hydrous aprotic polar solvent in the presence of a sodium boron hydride compound. A process for preparing a 1,2-ethanediol derivative in a high yield by esterifying an α-hydroxy carboxylic acid derivative to synthesize an α-hydroxy carboxylic acid ester derivative, and reducing this ester derivative in a protic solvent or a hydrous aprotic polar solvent in the presence of a sodium borohydride compound in the same reaction vessel.

  一种在氢化硼钠化合物存在下，通过在原生溶剂或含水非丙烯极性溶剂中还原 α-羟基羧酸酯衍生物，以高产率制备 1，2-乙二醇衍生物的工艺。一种通过酯化α-羟基羧酸衍生物合成α-羟基羧酸酯衍生物，并在同一反应容器中，在有硼氢化钠化合物存在的情况下，在质子溶剂或含水非丙烷极性溶剂中还原该酯衍生物，从而高产率制备1，2-乙二醇衍生物的工艺。
• TRANSFORMANT PRODUCING SECONDARY METABOLITE MODIFIED WITH FUNCTIONAL GROUP AND NOVEL BIOSYNTHESIS GENES
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1223215A1

  公开（公告）日：2002-07-17

  An objective of the present invention is to provide a transformant altered so as to produce a secondary metabolite in which a benzene ring of the secondary product is modified at the para-position with a functional group containing a nitrogen atom. A transformant according to the present invention is a transformant of an organism producing a secondary metabolite having a benzene ring skeleton without substitution at the para-position with a functional group containing a nitrogen atom, said transformant being transformed by introducing a gene involved in a biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid so as to produce a secondary metabolite having a benzene ring skeleton substituted at the para-position with a functional group containing a nitrogen atom. Another objective of the present invention is to provide a novel gene involved in the biosynthetic pathway from chorismic acid to p-aminophenylpyruvic acid. A novel gene according to the present invention comprises genes encoding the amino acid sequences of SEQ ID NOs: 2, 4 and 6 or modified sequences thereof.

  本发明的一个目的是提供一种转化体，这种转化体经过改变后可产生次级代谢产物，其中 次级产物的苯环在对位上被含有氮原子的官能团修饰。根据本发明，一种转化体是产生具有苯环骨架的次级代谢产物的生物体的转化体，该次级代谢产物的苯环骨架在对位上未被含有氮原子的官能团取代，所述转化体通过引入参与从络石酸到对氨基苯丙酮酸的生物合成途径的基因进行转化，从而产生具有苯环骨架的次级代谢产物，该次级代谢产物的苯环骨架在对位上被含有氮原子的官能团取代。本发明的另一个目的是提供一种参与从壳斗菜酸到对氨基苯基丙酮酸的生物合成途径的新型基因。根据本发明的新型基因包括编码 SEQ ID NOs: 2、4 和 6 的氨基酸序列或其修饰序列的基因。
• NOVEL (R)-2-HYDROXY-3-PHENYLPROPIONATE (D-PHENYLLACTATE) DEHYDROGENASE AND GENE ENCODING THE SAME
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1291417A1

  公开（公告）日：2003-03-12

  An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.

  本发明的一个目的是提供一种 D-苯基乳酸脱氢酶。本发明的另一个目的是提供一种编码 D-苯乳酸脱氢酶的基因。根据本发明的 D-苯基乳酸脱氢酶是一种蛋白质，它包含 SEQ ID NO: 2 氨基酸序列或 SEQ ID NO: 2 氨基酸序列的修饰氨基酸序列，该修饰氨基酸序列具有选自取代、缺失、添加和插入的一种或多种修饰，并具有 D-苯基乳酸脱氢酶活性。根据本发明的 D-苯基乳酸脱氢酶基因包括编码 D-苯基乳酸脱氢酶的核苷酸序列，例如 SEQ ID NO: 1 的核苷酸序列。
• Novel (r)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
  申请人：——

  公开号：US20030186410A1

  公开（公告）日：2003-10-02

  An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid dehydrogenase. A D-phenyllactic acid dehydrogenase according to the present invention is a protein comprising an amino acid sequence of the amino acid sequence of SEQ ID NO: 2 or a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that has one or more modifications selected from a substitution, a deletion, an addition and an insertion and has D-phenyllactic acid dehydrogenase activity. A D-phenyllactic acid dehydrogenase gene according to the present invention comprises a nucleotide sequence which encodes the D-phenyllactic acid dehydrogenase, for example the nucleotide sequence of SEQ ID NO: 1.

  本发明的一个目的是提供一种 D-苯基乳酸脱氢酶。本发明的另一个目的是提供一种编码 D-苯乳酸脱氢酶的基因。根据本发明的 D-苯基乳酸脱氢酶是一种蛋白质，它包含 SEQ ID NO: 2 氨基酸序列或 SEQ ID NO: 2 氨基酸序列的修饰氨基酸序列，该修饰氨基酸序列具有选自取代、缺失、添加和插入的一种或多种修饰，并具有 D-苯基乳酸脱氢酶活性。根据本发明的 D-苯基乳酸脱氢酶基因包括编码 D-苯基乳酸脱氢酶的核苷酸序列，例如 SEQ ID NO: 1 的核苷酸序列。