Tocris-1610

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: Tocris-1610
• 英文别名: (Z)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one
• 化学式: C₃₀H₂₈O₈
• 分子量: 516.5
• InChiKey: DEZFNHCVIZBHBI-KHPPLWFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Cancer stem cell immortalization
  申请人：Prochownik Edward A.

  公开号：US20110244472A1

  公开（公告）日：2011-10-06

  The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds as well as molecules critical to carcinogenesis. Further, cancer stem cells may be harvested from a patient and used, according to the invention, to select agents more likely to be effective in treating the cancer of that particular patient.
• [EN] CANCER STEM CELL IMMORTALIZATION<br/>[FR] IMMORTALISATION DE CELLULES SOUCHES CANCÉREUSES
  申请人：UNIV PITTSBURGH

  公开号：WO2009140260A2

  公开（公告）日：2009-11-19

  The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds as well as molecules critical to carcinogenesis. Further, cancer stem cells may be harvested from a patient and used, according to the invention, to select agents more likely to be effective in treating the cancer of that particular patient.