3-[4-(Propan-2-yl)anilino]phenol | 236095-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[4-(Propan-2-yl)anilino]phenol
• 英文别名: 3-(4-propan-2-ylanilino)phenol
• CAS: 236095-50-4
• 化学式: C₁₅H₁₇NO
• 分子量: 227.3
• InChiKey: JJYFTCHATMYUMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Novel alpha adrenergic agents
  申请人：——

  公开号：US20030092741A1

  公开（公告）日：2003-05-15

  Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men. 1 wherein: R 1 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, carboxy, amino, cyclohexyl, C 1 -C 6 alkylamino, or (C 1 -C 6 alkyl) 2 amino; R 2 is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, carboxy, amino, C 1 -C 6 alkylamino, or (C 1 -C 6 alkyl) 2 amino; R 3 is a group of the formula 2 R 4 is hydrogen or C 1 -C 6 alkyl; R 5 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, carboxy, amino, C 1 -C 6 alkylamino, or (C 1 -C 6 alkyl) 2 amino; and R 6 is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, carboxy, amino, C 1 -C 6 alkylamino, or (C 1 -C 6 alkyl) 2 amino; or pharmaceutically acceptable salts thereof

  本发明涉及一种用于治疗人类勃起障碍的化合物的公式I，包括男性勃起功能障碍。其中：R1为氢、卤素、羟基、硝基、氰基、苯基、三氟甲基、C1-C6烷基、C1-C6烷氧基、羧基、氨基、环己基、C1-C6烷基氨基或（C1-C6烷基）2氨基；R2为氢、卤素、羟基、硝基、氰基、三氟甲基、C1-C6烷基、C1-C6烷氧基、羧基、氨基、C1-C6烷基氨基或（C1-C6烷基）2氨基；R3为式2的基团；R4为氢或C1-C6烷基；R5为氢、卤素、羟基、硝基、氰基、苯基、三氟甲基、C1-C6烷基、C1-C6烷氧基、羧基、氨基、C1-C6烷基氨基或（C1-C6烷基）2氨基；R6为氢、卤素、羟基、硝基、氰基、三氟甲基、C1-C6烷基、C1-C6烷氧基、羧基、氨基、C1-C6烷基氨基或（C1-C6烷基）2氨基；或其药用盐。
• NOVEL ALPHA ADRENERGIC AGENTS
  申请人：Molecular Design International Inc.

  公开号：EP1418907A1

  公开（公告）日：2004-05-19
• EP1418907A4
  申请人：——

  公开号：EP1418907A4

  公开（公告）日：2004-10-20
• US6919357B2
  申请人：——

  公开号：US6919357B2

  公开（公告）日：2005-07-19
• [EN] NOVEL ALPHA ADRENERGIC AGENTS<br/>[FR] NOUVEAUX AGENTS A EFFET ALPHA ADRENERGIQUE
  申请人：MOLECTULAR DESIGN INTERNAT INC

  公开号：WO2003013515A1

  公开（公告）日：2003-02-20

  Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men (I), wherein: R1 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6 alkyl, C1- C6 alkoxy, carboxy, amino, cyclohexyl, C1-C6 alkyl amino, or (C1-C6 alkyl)2amino; R2 is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, carboxy, amino, C1-∩6 alkyl amino, or (C1-C6 alkyl)2amino; R3 is a group of the formula R4 is hydrogen or C1-C6 alkyl; R5 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6 alkyl, C1- C6 alkoxy, carboxy, amino, C1-C6 alkylamino, or (C1-C6 alkyl)2amino; and is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, carboxy, amino, C1-C6 alkyl amino, or (C1-C6 alkyl)2amino; or pharmaceutically acceptable salts thereof.