2-benzyl-4-methanesulfonylamino-6-(4-methoxyphenyl)-2H-pyridazin-3-one | 243862-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-benzyl-4-methanesulfonylamino-6-(4-methoxyphenyl)-2H-pyridazin-3-one
• 英文别名: N-[2-benzyl-6-(4-methoxyphenyl)-3-oxopyridazin-4-yl]methanesulfonamide
• CAS: 243862-84-2
• 化学式: C₁₉H₁₉N₃O₄S
• 分子量: 385.444
• InChiKey: OKYZMEBNTMMYBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  96.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-benzyl-4-dimethanesulfonylamino-6-(4-methoxyphenyl)-2H-pyridazin-3-one 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以86.9%的产率得到2-benzyl-4-methanesulfonylamino-6-(4-methoxyphenyl)-2H-pyridazin-3-one
  参考文献：
  名称：

  Pyridazine derivatives and drugs containing the same as the active ingredient

  摘要：

  这项发明涉及由式（1）表示的吡啶嗪衍生物： 其中R1代表较低的烷氧基团、较低的烷硫基团或卤原子；R2代表H、较低的烷氧基团、较低的烷硫基团或卤原子；R3代表较低的烷基或较低的烯基，可以被一个或多个OH、CN、较低的环烷基、（取代的）芳香基或（取代的）氨基甲酰基取代；R4代表COOH、较低的烷氧羰基团、（取代的）氨基甲酰基、（取代的）氨基团或（取代的）脲基；虚线表示4位和5位之间的碳-碳键是单键或双键，或其盐；以及含有它们作为有效成分的药物。这些化合物对白细胞介素-1β的产生具有出色的抑制活性，并可用作免疫系统疾病、炎症性疾病、缺血性疾病等的预防和治疗药物。

  公开号：

  US06403586B1

文献信息

• NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Kowa Co., Ltd.

  公开号：EP1061077A1

  公开（公告）日：2000-12-20

  This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a lower alkoxyl group, a lower alkylthio group or a halogen atom; R2 represents H, a lower alkoxyl group, a lower alkylthio group or a halogen atom; R3 represents a lower alkyl or lower alkenyl group, which may be substituted by one or more OHs, CNs, lower cycloalkyl groups, (substituted) aromatic groups or (substituted) carbamoyl groups; R4 represents COOH, a lower alkoxycarbonyl group, a (substituted) carbamoyl group, a (substituted) amino group, or a (substituted) ureido group; and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1β production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.

  本发明涉及式（1）所代表的哒嗪衍生物： 其中 R1 代表低级烷氧基、低级烷硫基或卤原子；R2 代表 H、低级烷氧基、低级烷硫基或卤原子；R3 代表低级烷基或低级烯基，可被一个或多个 OH、CN、低级环烷基、（取代的）芳香基团或（取代的）氨基甲酰基取代；R4 代表 COOH、低级烷氧羰基、（取代的）氨基甲酰基、（取代的）氨基或 （取代的）脲基；虚线表示 4 位和 5 位之间的碳-碳键为单键或双键，或其盐类；以及含有它们作为有效成分的药物。这些化合物对白细胞介素-1β的产生具有良好的抑制活性，可作为免疫系统疾病、炎症性疾病、缺血性疾病等的预防和治疗药物。
• US6403586B1
  申请人：——

  公开号：US6403586B1

  公开（公告）日：2002-06-11
• Pyridazine derivatives and drugs containing the same as the active ingredient
  申请人：Kowa Co., Ltd.

  公开号：US06403586B1

  公开（公告）日：2002-06-11

  This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a lower alkoxyl group, a lower alkylthio group or a halogen atom; R2 represents H, a lower alkoxyl group, a lower alkylthio group or a halogen atom; R3 represents a lower alkyl or lower alkenyl group, which may be substituted by one or more OHs, CNs, lower cycloalkyl groups, (substituted) aromatic groups or (substituted) carbamoyl groups; R4 represents COOH, a lower alkoxycarbonyl group, a (substituted) carbamoyl group, a (substituted) amino group, or a (substituted) ureido group; and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1&bgr; production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.

  这项发明涉及由式（1）表示的吡啶嗪衍生物： 其中R1代表较低的烷氧基团、较低的烷硫基团或卤原子；R2代表H、较低的烷氧基团、较低的烷硫基团或卤原子；R3代表较低的烷基或较低的烯基，可以被一个或多个OH、CN、较低的环烷基、（取代的）芳香基或（取代的）氨基甲酰基取代；R4代表COOH、较低的烷氧羰基团、（取代的）氨基甲酰基、（取代的）氨基团或（取代的）脲基；虚线表示4位和5位之间的碳-碳键是单键或双键，或其盐；以及含有它们作为有效成分的药物。这些化合物对白细胞介素-1β的产生具有出色的抑制活性，并可用作免疫系统疾病、炎症性疾病、缺血性疾病等的预防和治疗药物。