3-(1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}-ethyl)benzenecarboxamidine | 288309-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}-ethyl)benzenecarboxamidine
• 英文别名: 3-(3-carbamimidoylphenyl)-4-methoxy-N-[4-(2-sulfamoylphenyl)phenyl]butanamide
• CAS: 288309-42-2
• 化学式: C₂₄H₂₆N₄O₄S
• 分子量: 466.561
• InChiKey: KHFONWDTRVQHBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-((1E)-1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}vinyl)benzenecarboxamidine 、 氢气 在 钯 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以to give 3-(1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}-ethyl)benzenecarboxamidine (5 mg, 100%) as a fluffy white powder的产率得到3-(1-(methoxymethyl)-2-{N-[4-(2-sulfamoylphenyl)phenyl]carbamoyl}-ethyl)benzenecarboxamidine
  参考文献：
  名称：

  Inhibitors of factor Xa

  摘要：

  本发明揭示了具有对哺乳动物因子Xa活性的新化合物、其盐和相关组合物。这些化合物在体内或体外中用于预防或治疗凝血障碍。

  公开号：

  US06399627B1

文献信息

• INHIBITORS OF FACTOR Xa
  申请人：COR THERAPEUTICS, INC.

  公开号：EP1159264A2

  公开（公告）日：2001-12-05
• US6399627B1
  申请人：——

  公开号：US6399627B1

  公开（公告）日：2002-06-04
• [EN] INHIBITORS OF FACTOR Xa<br/>[FR] INHIBITEURS DU FACTEUR Xa
  申请人：COR THERAPEUTICS INC

  公开号：WO2000047554A2

  公开（公告）日：2000-08-17

  Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammalian Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
• [EN] INHIBITORS OF FACTOR Xa<br/>[FR] INHIBITEURS DU FACTEUR XA
  申请人：COR THERAPEUTICS INC

  公开号：WO2000071512A1

  公开（公告）日：2000-11-30

  The present application relates to compounds of the general formula A-Y-D-E-G-J-Z-L, wherein A, Y, D, E, G, J, Z and L have the meanings given in the description, having activity against mammalian factor Xa. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
• Inhibitors of factor Xa
  申请人：Cor Therapeutics, Inc.

  公开号：US06399627B1

  公开（公告）日：2002-06-04

  Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

  披露了新型化合物、它们的盐和与它们相关的组合物，这些化合物对哺乳动物因子Xa具有活性。这些化合物在体外或体内用于预防或治疗凝血障碍。