2-(pyridin-2-ylmethylideneamino)guanidine;hydrochloride | 2971-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(pyridin-2-ylmethylideneamino)guanidine;hydrochloride
• CAS: 2971-91-7
• 化学式: C₇H₉N₅*2ClH
• 分子量: 236.104
• InChiKey: TWNFNIYCDUUANN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.11
• 重原子数：
  13.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.65
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  1-(2-pyridylmethinyl)amino-S-methylisothiourea hydroiodide 在 氨 作用下， 以 甲苯 为溶剂， 生成 2-(pyridin-2-ylmethylideneamino)guanidine;hydrochloride
  参考文献：
  名称：

  2-，4-吡啶和4-喹啉羧酸醛的胍基hy​​dr的合成及生物活性

  摘要：

  使用已知的方法，由S-甲基异硫代-半氨基脲氢碘化物合成了一系列衍生自2-和4-吡啶和4-喹啉羧醛的胍基hy​​dr。该化合物类似于抗癌和抗病毒的硫代半氨基甲酰氮，但几种衍生自4-喹啉羧甲醛的胍基showed酮对小鼠的P388淋巴细胞性白血病没有活性。然而，衍生自所有三个杂环醛的鸟嘌呤hydr酮在大鼠中显示出显着的降血压作用。

  DOI：

  10.1002/jps.2600790615

文献信息

• Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase
  作者：Elaine da Conceição Petronilho、Magdalena do Nascimento Rennó、Newton Gonçalves Castro、Fernanda Motta R. da Silva、Angelo da Cunha Pinto、José Daniel Figueroa-Villar

  DOI：10.3109/14756366.2015.1094468

  日期：2016.11.1

  Analogs of pralidoxime, which is a commercial antidote for intoxication from neurotoxic organophosphorus compounds, were designed, synthesized, characterized, and tested as potential inhibitors or reactivators of acetylcholinesterase (AChE) using the Ellman's test, nuclear magnetic resonance, and molecular modeling. These analogs include 1-methylpyridine-2-carboxaldehyde hydrazone, 1-methylpyridine-2-carboxaldehyde guanylhydrazone, and six other guanylhydrazones obtained from different benzaldehydes. The results indicate that all compounds are weak AChE reactivators but relatively good AChE inhibitors. The most effective AChE inhibitor discovered was the guanylhydrazone derived from 2,4-dinitrobenzaldehyde and was compared with tacrine, displaying similar activity to this reference material. These results indicate that guanylhydrazones as well as future similar derivatives may function as drugs for the treatment of Alzheimer's disease.
• Synthesis and Biological Activity of Guanylhydrazones of 2- and 4-Pyridine and 4-Quinoline Carboxaldehydes
  作者：William O. Foye、Bijan Almassian、Marc S. Eisenberg、Timothy J. Maher

  DOI：10.1002/jps.2600790615

  日期：1990.6

  A series of guanylhydrazones derived from 2- and 4-pyridine and 4-quinoline carboxyaldehydes was synthesized from S-methylisothio-semicarbazide hydroiodide using known procedures. The compounds are analogous to anticancer and antiviral thiosemicarbazones, but several of the guanylhydrazones derived from 4-quinoline carboxaldehyde showed no activity against P388 lymphocytic leukemia in mice. Guanylhydrazones

  使用已知的方法，由S-甲基异硫代-半氨基脲氢碘化物合成了一系列衍生自2-和4-吡啶和4-喹啉羧醛的胍基hy​​dr。该化合物类似于抗癌和抗病毒的硫代半氨基甲酰氮，但几种衍生自4-喹啉羧甲醛的胍基showed酮对小鼠的P388淋巴细胞性白血病没有活性。然而，衍生自所有三个杂环醛的鸟嘌呤hydr酮在大鼠中显示出显着的降血压作用。