3,4-Dihydro-2-dimethylamino-4-oxopyrimidine-5-carboxylic acid | 186130-63-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,4-Dihydro-2-dimethylamino-4-oxopyrimidine-5-carboxylic acid
• 英文别名: 2-(Dimethylamino)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid；2-(dimethylamino)-6-oxo-1H-pyrimidine-5-carboxylic acid
• CAS: 186130-63-2
• 化学式: C₇H₉N₃O₃
• 分子量: 183.167
• InChiKey: UDHLCPYPCPDMQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(二甲基氨基)-6-氧代-1,6-二氢嘧啶-5-羧酸乙酯 、 sodium hydroxide 、 盐酸 以 水 为溶剂， 反应 2.0h， 以to give title compound (0.52 g)的产率得到3,4-Dihydro-2-dimethylamino-4-oxopyrimidine-5-carboxylic acid
  参考文献：
  名称：

  Heterocyclic mutilin esters and their use as antibacterials

  摘要：

  公式为的Pleuromutilin化合物在抗菌疗法中有用。

  公开号：

  US06878704B2

文献信息

• USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS
  申请人：Subkowski Thomas

  公开号：US20120263659A1

  公开（公告）日：2012-10-18

  The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

  这项发明涉及一种TRPM8调节剂，用于在皮肤或粘膜上产生降温效果。
• USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS
  申请人：BASF SE

  公开号：US20200190052A1

  公开（公告）日：2020-06-18

  The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

  该发明主要涉及一种调制方法，优选是体外和/或体内调制寒冷薄荷醇受体TRPM8的方法，其中受体与本文描述的结构类型1的化合物群中至少一种调制剂接触。本发明还涉及相关用途和包含这些化合物的组合物。
• N-phenylcarbamates having a microbicide insecticide and acaricide effect
  申请人：——

  公开号：US20040023806A1

  公开（公告）日：2004-02-05

  The invention relates to novel compounds of the formula I 1 in which A is —CH 2 O— or —CH═N—; R 1 is C 1 -C 4 -alkyl or cyclopropyl; R 2 is C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl or C 2 -C 6 -alkynyl or is C 1 -C 6 -alkyl substituted by from 1 to 5 fluorine atoms; R 3 denotes the radicals defined in the description; R 5 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 2 -alkoxymethyl, C 1 -C 2 -alkylthiomethyl, C 1 -C 3 -haloalkylmethyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 1 -C 3 -alkylcarbonyl or C 1 -C 2 -alkoxycarbonyl, and R 6 is C 1 -C 4 -alkyl, which are suitable in agriculture for controlling acarids and insects and for preventing the infestation of crop plants by phytopathogenic fungi.

  该发明涉及一种新的化合物，其化学式为I1，其中A为—CH2O—或—CHN—；R1为C1-C4-烷基或环丙基；R2为C1-C6-烷基、C2-C6-烯基或C2-C6-炔基，或者为被1至5个氟原子取代的C1-C6-烷基；R3表示描述中定义的基团；R5为氢、C1-C4-烷基、C1-C2-烷氧甲基、C1-C2-烷基硫甲基、C1-C3-卤代烷基甲基、C2-C4-烯基、C2-C4-炔基、C1-C3-烷基羰基或C1-C2-烷氧羰基；R6为C1-C4-烷基，适用于农业用于控制蜘蛛和昆虫，以及预防作物植物受植物病原真菌侵害。
• LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF
  申请人：BASF SE

  公开号：US20170265510A1

  公开（公告）日：2017-09-21

  The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.

  本发明涉及新型的冷薄荷感受受体TRPM8的调制剂，以及利用这些调制剂调节TRPM8受体的方法；特别是利用这些调制剂诱导寒冷感觉的用途；以及利用这些调制剂生产的文章和组合物。
• Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof
  申请人：BASF SE

  公开号：US10398159B2

  公开（公告）日：2019-09-03

  The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.

  本发明涉及新型的冷薄荷受体 TRPM8 调节剂，使用这些调节剂调节 TRPM8 受体的方法；特别是使用这些调节剂诱导冷感；以及使用这些调节剂生产的物品和组合物。