1-(3-Chloro-phenoxy)-3-(triphenyl-λ⁵-phosphanylidene)-propan-2-one | 73718-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Chloro-phenoxy)-3-(triphenyl-λ⁵-phosphanylidene)-propan-2-one
• 英文别名: 1-(3-Chlorophenoxy)-3-(triphenyl-lambda~5~-phosphanylidene)propan-2-one；1-(3-chlorophenoxy)-3-(triphenyl-λ5-phosphanylidene)propan-2-one
• CAS: 73718-87-3
• 化学式: C₂₇H₂₂ClO₂P
• 分子量: 444.897
• InChiKey: IKMJLBBGBDMUEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-Chloro-phenoxy)-3-(triphenyl-λ⁵-phosphanylidene)-propan-2-one 、 (Z)-7-[(2S,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-tetrahydro-furan-3-yl]-hept-4-enoic acid isopropyl ester 在 高碘酸 、 溶剂黄146 作用下， 以 醋酸异丙酯 、 二氯甲烷 为溶剂， 生成 (Z)-7-{(2R,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-[(E)-4-(3-chloro-phenoxy)-3-oxo-but-1-enyl]-tetrahydro-furan-3-yl}-hept-4-enoic acid isopropyl ester
  参考文献：
  名称：

  AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey

  摘要：

  A series of 11-oxa prostaglandin analogs was evaluated for FP receptor binding and activation. Several compounds having aryloxy-terminated lower chains were found to be potent agonists. Topical ocular dosing of AL-12182, the isopropyl ester prodrug of the potent agonist 13, lowered intraocular pressure in the monkey by 40% accompanied by minimal conjunctival hyperemia in the rabbit. AL-12182 was synthesized on multigram scale starting with D-sorbitol. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.037

文献信息

• Processes and novel intermediates for 11-oxa prostaglandin synthesis
  申请人：——

  公开号：US20020002284A1

  公开（公告）日：2002-01-03

  Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.

  本发明揭示了用于制备11-氧代前列腺素类似物的新工艺和中间体。
• Process for use in 11-oxa prostaglandin synthesis
  申请人：——

  公开号：US20040063968A1

  公开（公告）日：2004-04-01

  Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.

  本发明揭示了在制备11-氧代前列腺素类似物时有用的新工艺和中间体。
• Compounds for use in 11-oxa prostaglandin synthesis
  申请人：——

  公开号：US20030013884A1

  公开（公告）日：2003-01-16

  Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.

  本发明揭示了在制备11-氧代前列腺素类似物中有用的新工艺和中间体。
• US6441196B2
  申请人：——

  公开号：US6441196B2

  公开（公告）日：2002-08-27
• US6620947B2
  申请人：——

  公开号：US6620947B2

  公开（公告）日：2003-09-16