(E,7R)-7-methoxy-1-piperidin-1-yltetradec-4-en-1-one | 1421455-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (E,7R)-7-methoxy-1-piperidin-1-yltetradec-4-en-1-one
• CAS: 1421455-04-0
• 化学式: C₂₀H₃₇NO₂
• 分子量: 323.519
• InChiKey: SHEHGPREIYXOHF-QPGLYAHGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (R)-decane-1,3-diol 在 咪唑 、 4-二甲氨基吡啶 、 Jones reagent 、 四丁基氟化铵 、 sodium hydride 、 1-羟基苯并三唑 、 对甲苯磺酸 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 lithium hexamethyldisilazane 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 二甲基亚砜 、 丙酮 、 mineral oil 为溶剂， 反应 54.0h， 生成 (E,7R)-7-methoxy-1-piperidin-1-yltetradec-4-en-1-one
  参考文献：
  名称：

  Novel malyngamide structural analogs: synthesis and biological evaluation

  摘要：

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.

  DOI：

  10.1007/s00044-013-0466-y

文献信息

• Novel malyngamide structural analogs: synthesis and biological evaluation
  作者：G. Venkateswar Reddy、T. Vijaya Kumar、B. Siva、K. Suresh Babu、P. V. Srinivas、Irum Sehar、A. K. Saxena、J. Madhusudana Rao

  DOI：10.1007/s00044-013-0466-y

  日期：2013.10

  In the course of our search for new anticancer agents, a series of novel malyngamide derivatives were synthesized by sharpless asymmetric epoxidation, followed by Julia-Kocinski olefination reactions as key reaction sequence. Anticancer activities of all these derivatives were screened against IMR-32, SF-295, SKNSH, HeLa, Colon-502713, SW-620, and Hop-62 cell lines for the first time.