1-(2-bromoethoxy)-4-isopropylbenzene | 467236-24-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-bromoethoxy)-4-isopropylbenzene
• 英文别名: 1-(2-bromoethoxy)-4-propan-2-ylbenzene
• CAS: 467236-24-4
• 化学式: C₁₁H₁₅BrO
• 分子量: 243.143
• InChiKey: UZKXBHFWGVLECL-UHFFFAOYSA-N

物化性质

• 沸点：
  288.4±33.0 °C(Predicted)
• 密度：
  1.258±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(2-bromoethoxy)-4-isopropylbenzene 、 3-(Furan-3-yl)-6-hydroxy-2-pyridin-3-ylinden-1-one 在 potassium carbonate 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-(Furan-3-yl)-6-[2-(4-propan-2-ylphenoxy)ethoxy]-2-pyridin-3-ylinden-1-one
  参考文献：
  名称：

  WO2024005578A1

  摘要：

  公开号：

文献信息

• [EN] LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF<br/>[FR] PROMEDICAMENTS DE LEVODOPA, ET COMPOSITIONS ET LEURS UTILISATIONS
  申请人：XENOPORT INC

  公开号：WO2005121070A1

  公开（公告）日：2005-12-22

  Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Formula (I), n is an integer from 1 to 6; R5 is selected from alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroalyl, substituted heteroalyl, heteroalylalkyl, and substituted heteroalylalkyl.

  本文披露了左旋多巴的前药、制备左旋多巴前药的方法、使用左旋多巴前药的方法以及左旋多巴前药的组合物。其中，公式（I）中，n为1至6的整数；R5选自烷基、取代烷基、芳基、取代芳基、芳基烷基、取代芳基烷基、环烷基、取代环烷基、杂烷基、取代杂烷基、环杂烷基、取代环杂烷基、杂烯基、取代杂烯基、杂烯基烷基和取代杂烯基烷基。
• Carboxylic acids
  申请人：——

  公开号：US20040116708A1

  公开（公告）日：2004-06-17

  The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. 1 In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): 2 (wherein Z represents a group represented by the formula (IV): 3 (wherein R 9 , R 10 , R 11 and R 12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

  本发明提供了一种新的羧酸衍生物，其盐或水合物可用作胰岛素增敏剂，并提供了一种以该衍生物为有效成分的药物。更具体地，本发明提供了一种由式(I)表示的羧酸化合物，其盐或水合物。在式中，Ar表示一个有6至14个成员的芳香环基团，该基团可以具有至少一个取代基；R1，R2，R3，R4，R5，R6，R7和R8相同或不同，每个表示氢原子，卤素原子，羟基，C1-6烷基或C1-6烷氧基；X表示氧原子或亚甲基；Y表示由式(II)或(III)表示的基团：其中Z表示由式(IV)表示的基团：其中R9，R10，R11和R12相同或不同，每个表示氢原子，卤素原子，羟基，C1-6烷基或C1-6烷氧基）；m为0或1；n为0或1。
• Carboxylic acid derivative and salt thereof
  申请人：——

  公开号：US20040102634A1

  公开（公告）日：2004-05-27

  The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. 1 Wherein R 1 represents a hydrogen atom, hydroxyl group, halogen, carboxyl group, or a C 1-6 alkyl group etc., each of which may have one or more substituents; L represents a single bond, or a C 1-6 alkylene group, a C 2-6 alkenylene group or a C 2-6 alkynylene group, each of which may have one or more substituents; M represents a single bond, or a C 1-6 alkylene group, a C 2-6 alkenylene group or a C 2-6 alkynylene group, each of which may have one or more substituents; T represents a single bond, or a C 1-3 alkylene group, a C 2-3 alkenylene group or a C 2-3 alkynylene group, each of which may have one or more substituents; W represents a carboxyl group; 2 represents a single bond etc.; X represents a single bond, oxygen atom, a group represented by —NR X1 CQ 1 O— (wherein Q 1 represents an oxygen atom or sulfur atom; and R X1 represents a hydrogen atom, formyl group, or a C 1-6 alkyl group etc., each of which may have one or more substituents), —OCQ 1 NR X1 — (wherein Q 1 and R X1 are as defined above), —CQ 1 NR X1 O— (wherein Q 1 and R X1 are as defined above), ONR X1 CQ 1 — (wherein Q 1 and R X1 are as defined above), -Q 2 SO 2 — (wherein Q 2 is an oxygen atom or —NR X10 — (wherein R X10 represents a hydrogen atom, formyl group, or a C 1-6 alkyl group etc., each of which may have one or more substituents)) or —SO 2 Q 2 - (wherein Q 2 is as defined above), (wherein, provided that R X2 and R X3 , and/or R X4 and R X5 may together form a ring, Q 3 and Q 4 are the same as or different from each other and each represents an oxygen atom, (O)S(O) or NR X10 (wherein NR X10 is as defined above)); Y represents a 5- to 14-membered aromatic group etc., which may have one or more substituents and one or more hetero atoms; and the ring Z represents a 5- to 14-membered aromatic group which may have 0 to 4 substituents and one or more hetero atoms, and wherein part of the ring may be saturated.

  本发明提供了一种新型的羧酸化合物、其盐或水合物，作为胰岛素增敏剂，并且提供了一种包含该化合物作为活性成分的药物。即，本发明提供了由以下式表示的羧酸化合物、其盐、酯或水合物。其中，R1表示氢原子、羟基、卤素、羧基或C1-6烷基等，每个都可以有一个或多个取代基；L表示单键，或C1-6烷基、C2-6烯基或C2-6炔基等，每个都可以有一个或多个取代基；M表示单键，或C1-6烷基、C2-6烯基或C2-6炔基等，每个都可以有一个或多个取代基；T表示单键，或C1-3烷基、C2-3烯基或C2-3炔基等，每个都可以有一个或多个取代基；W表示羧基；2表示单键等；X表示单键、氧原子、由—NRX1CQ1O—表示的基团（其中，Q1表示氧原子或硫原子；RX1表示氢原子、甲酰基或C1-6烷基等，每个都可以有一个或多个取代基）、由—OCQ1NRX1—表示的基团（其中，Q1和RX1如上所定义）、由—CQ1NRX1O—表示的基团（其中，Q1和RX1如上所定义）、由ONRX1CQ1—表示的基团（其中，Q1和RX1如上所定义）、由-Q2SO2—表示的基团（其中，Q2是氧原子或—NRX10—（其中，RX10表示氢原子、甲酰基或C1-6烷基等，每个都可以有一个或多个取代基））或由—SO2Q2—表示的基团（其中，Q2如上所定义），（其中，假设RX2和RX3，以及RX4和RX5可以共同形成环，Q3和Q4相同或不同，每个表示氧原子、（O）S（O）或NRX10（其中，NRX10如上所定义））；Y表示5-至14-成员芳香基等，可以有一个或多个取代基和一个或多个杂原子；环Z表示5-至14-成员芳香基，可以有0至4个取代基和一个或多个杂原子，其中环的一部分可以饱和。
• Cyclic compound and ppar agonist
  申请人：Clark Richard

  公开号：US20050014833A1

  公开（公告）日：2005-01-20

  The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R 1 to R 6 are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.; A 1 and A 2 are the same as or different from each other and each represents a single bond, an oxygen atom, etc.; L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.; W represents a carboxyl group; the partial structure represented by the formula: represents a single bond or a double bond; X represents a single bond, an oxygen atom, —NR X1 CQ 1 O—, etc.; Y represents Y 1 —Y 2 — (wherein Y 1 represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y 2 represents a single bond or a 5 to 14-membered aromatic ring); and the ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.

  本发明提供了一种具有出色PPAR激动剂作用的新化合物。更具体地说，它提供了一种由以下公式表示的化合物，其盐，酯或水合物。其中a，b和c彼此相同或不同，每个表示0到4; R1至R6彼此相同或不同，每个表示氢原子，羟基，氰基，卤素原子等; A1和A2彼此相同或不同，每个表示单键，氧原子等; L，M和T每个表示单键，具有一到六个碳原子的烷基等; W表示羧基;由以下公式表示的部分结构:表示单键或双键; X表示单键，氧原子，-NRX1CQ1O-等; Y表示Y1-Y2-（其中Y1表示具有一到四个取代基的5到14个成员的芳香环等; Y2表示单键或5到14个成员的芳香环）; 而环Z表示从上述A族中选择的具有一到四个取代基的5到14个成员的芳香环，可以具有一个或多个杂原子，并且可以部分饱和。
• CARBOXYLIC ACIDS
  申请人：Eisai Co., Ltd.

  公开号：EP1375484A1

  公开（公告）日：2004-01-02

  The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

  本发明提供了一种可用作胰岛素增敏剂的新型羧酸衍生物、其盐或其水合物，以及以该衍生物为有效成分的药物。更具体地说，它提供了一种由式（I）代表的羧酸化合物、其盐或它们的水合物。 式中，Ar代表6-至14元芳香环基，该环基可具有至少一个取代基；R1、R2、R3、R4、R5、R6、R7和R8彼此相同或不同，且各自代表氢原子、卤素原子、羟基、C1-6烷基或C1-6烷氧基；X代表氧原子或亚甲基；Y代表由式(II)或(III)代表的基团： (其中 Z 代表由式（IV）代表的基团： (其中 R9、R10、R11 和 R12 彼此相同或不同，且各自代表氢原子、卤素原子、羟基、C1-6 烷基或 C1-6 烷氧基））；m 为 0 或 1；n 为 0 或 1。