2-chloro-6-ethylimidazo[1,2-b]pyridazine | 570416-44-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-chloro-6-ethylimidazo[1,2-b]pyridazine
• CAS: 570416-44-3
• 化学式: C₈H₈ClN₃
• 分子量: 181.625
• InChiKey: LZBVZAYVHQKORT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel process for producting imidazo[1,2-b]pyridazine derivative
  申请人：Tabuchi Takanori

  公开号：US20050171108A1

  公开（公告）日：2005-08-04

  A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): (wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I): (wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO 2 N═CH—NR 1 R 2 ; and Z represents halogeno or OSO 2 R 3 ) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.

  一种用于简便、低成本地生产具有取代基与6-位碳原子键合的咪唑[1,2-b]吡嗪-3-基磺酰胺衍生物的方法，其化学式表示为(II):(其中R代表低烷基、低环烷基(可选地被低烷基取代)、低烯基或低炔基)，该方法包括在过渡金属催化剂的存在下，将咪唑[1,2-b]吡嗪化合物与有机金属化合物反应，所述咪唑[1,2-b]吡嗪化合物的化学式表示为(I):(其中X代表卤素或低烷基(可选地被卤素取代)；Y代表氢或SO2N═CH—NR1R2；Z代表卤素或OSO2R3)。该衍生物可用作除草剂的中间体。
• Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same
  申请人：Tanaka Yasushi

  公开号：US20050032650A1

  公开（公告）日：2005-02-10

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供了一种由以下式子表示的化合物：其中Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代低烷基，可选的卤代低烷氧基等，或其盐，以及包含该化合物或其盐的除草剂，在稻田中对磺酰脲除草剂耐药杂草具有显著的控制效果，可以减少联合制剂中的活性成分数量，并且包括使用该化合物的控制磺酰脲除草剂耐药杂草的方法。
• PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND
  申请人：Nakazawa Koichi

  公开号：US20090247748A1

  公开（公告）日：2009-10-01

  A process for producing a sulfonyl chloride compound comprising: (A) a step comprising reacting a pyridazine compound represented by the formula (1): wherein R 1 represents a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, or the like, R 2 and R 3 are the same or different and each represents a hydrogen atom or the like, R 4 represent a hydrogen atom, a halogen atom, an alkyl group which may be substituted with a halogen atom or atoms, or the like, with a sulfonating agent; (B) a step comprising contacting the reaction mixture obtained in the step (A) with a chlorinating agent; and (C) a step comprising mixing the reaction mixture obtained in the step (B) with an aqueous inorganic base solution to separate an organic layer containing a sulfonyl chloride compound represented by the formula (2): wherein R 1 to R 4 are the same meanings as defined above.

  一种生产磺酰氯化合物的方法，包括以下步骤： （A）反应式（1）所表示的吡嗪化合物，其中R1表示氢原子、卤原子、可以用卤原子或其他基团取代的烷基基团等，R2和R3相同或不同，分别表示氢原子或类似物，R4表示氢原子、卤原子、可以用卤原子或其他基团取代的烷基基团等，与磺化试剂反应； （B）将步骤（A）中得到的反应混合物与氯化试剂接触； （C）将步骤（B）中得到的反应混合物与无机碱性水溶液混合，以分离出含有式（2）所表示的磺酰氯化合物的有机层，其中R1到R4的含义如上所定义。
• Fused heterocyclic sulfonylurea compound, herbicide containing the same, and method for controlling weed with the same
  申请人：Tanaka Yasushi

  公开号：US20100160163A1

  公开（公告）日：2010-06-24

  The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

  本发明提供了一种化合物，其表示为公式：其中Q代表融合的杂环基团，X和Y相同或不同，每个代表可选的卤代较低烷基基团，可选的卤代较低烷氧基团等，或其盐，以及包含该化合物或其盐的除草剂，该除草剂对水稻田中的磺酰脲除草剂抗性杂草具有显着的控制效果，并且可以减少组合制剂中活性成分的数量，以及使用该化合物来控制磺酰脲除草剂抗性杂草的方法。
• PHENOXYMETHYL HETEROCYCLIC COMPOUNDS
  申请人：ENVIVO PHAMACEUTICALS, INC.

  公开号：US20130143888A1

  公开（公告）日：2013-06-06

  Phenoxymethyl compounds that inhibit at least one phosphodiesterase 10 are described as are pharmaceutical compositions containing such compounds an methods for treating various CNS disorders by administering such compounds to a patient in need thereof.

  本文描述了抑制至少一种磷酸二酯酶10的苯甲氧基化合物，以及包含这些化合物的药物组合物和通过将这些化合物用于需要治疗的患者来治疗各种中枢神经系统疾病的方法。