4-Methylpyridine-2,6(1H,3H)-dione | 72692-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Methylpyridine-2,6(1H,3H)-dione
• 英文别名: 4-methyl-3H-pyridine-2,6-dione
• CAS: 72692-95-6
• 化学式: C₆H₇NO₂
• 分子量: 125.13
• InChiKey: OAGCYWTVNKSWKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 6-MEMBERED URACIL ISOSTERES<br/>[FR] ISOSTÈRES D'URACILE À 6 CHAÎNONS
  申请人：CV6 THERAPEUTICS NI LTD

  公开号：WO2018098204A1

  公开（公告）日：2018-05-31

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

  本文件提供了dUTPase抑制剂，包含此类化合物的组合物以及使用此类化合物和组合物的方法。
• Therapeutic amide derivatives
  申请人：Kawai Makoto

  公开号：US20070167452A1

  公开（公告）日：2007-07-19

  The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt or solvate thereof, to processes for the preparation of, intermediates used in the preparation of, compositions containing such compounds and the uses of such compounds as antagonists of the NMDA NR2B receptor.

  本发明涉及式(I)的化合物：或其药学上可接受的盐或溶剂，以及制备这些化合物的过程中使用的中间体，含有这些化合物的组合物及其作为NMDA NR2B受体拮抗剂的用途。
• N-CONTAINING HETEROCYCLIC COMPOUNDS
  申请人：Bourke David Gerard

  公开号：US20110092499A1

  公开（公告）日：2011-04-21

  The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

  本发明涉及一种含氮杂环化合物，其是蛋白激酶的抑制剂，包括JAK激酶。特别地，这些化合物对JAK1、JAK2、JAK3或TYK2激酶和它们的组合具有选择性，例如JAK1和JAK2。这些激酶抑制剂可用于治疗与激酶相关的疾病，例如免疫和炎症性疾病，包括器官移植；增生性疾病，包括癌症和骨髓增生性疾病；病毒性疾病；代谢性疾病；以及血管性疾病。
• N-BENZYL-4-METHYLENEAMINO-3-HYDROXY-2-PYRIDONES
  申请人：Warshakoon Namal Chithranga

  公开号：US20120115876A1

  公开（公告）日：2012-05-10

  Compounds of Formula (I) are effective in the treatment of a microbial infection.

  公式（I）的化合物对治疗微生物感染有效。
• Derivatives of Fluorene, Anthracene, Xanthene, Dibenzosuberone and Acridine and Uses Thereof
  申请人：Cholody Wieslaw M.

  公开号：US20120129837A1

  公开（公告）日：2012-05-24

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及一种化学试剂，例如芴，蒽，黄色素，二苯基甲酮和吖啶的二磺酰胺衍生物，以及类似的杂环环结构，包括其盐，作为抗癌和抗肿瘤试剂，特别是这些试剂能够调节Wnt/β-连环蛋白信号通路的活性，降低细胞中（如癌细胞）的β-连环蛋白水平，或者这些试剂调节细胞系统（包括癌细胞）中基因表达水平。同时，本发明还涉及制备这些试剂的方法，以及包含这些试剂作为活性成分的制药组合物和使用这些组合物作为治疗试剂的方法。