N-(3-cyano-4-methyl-1-n-propyl-1H-pyrrol-2-yl)-2-ethoxylbenzamide | 804519-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-cyano-4-methyl-1-n-propyl-1H-pyrrol-2-yl)-2-ethoxylbenzamide
• 英文别名: N-(3-Cyano-4-methyl-1-propyl-1H-pyrrol-2-yl)-2-ethoxybenzamide；N-(3-cyano-4-methyl-1-propylpyrrol-2-yl)-2-ethoxybenzamide
• CAS: 804519-28-6
• 化学式: C₁₈H₂₁N₃O₂
• 分子量: 311.384
• InChiKey: ZSIFECSDMNRMKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-cyano-4-methyl-1-n-propyl-1H-pyrrol-2-yl)-2-ethoxylbenzamide 以80的产率得到2-(2-ethoxylbenzamido)-4-methyl-1-n-propyl-1H-pyrrolo-3-formamide
  参考文献：
  名称：

  Process for making substituted pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of phosphodiesterase 5

  摘要：

  本发明涉及公式I的化合物，其制备方法以及含有该化合物的制药组合物。本发明还涉及使用公式I的化合物制备药物，可以治疗动物（包括人类（男性和女性））的性功能障碍，尤其是男性勃起功能障碍和涉及磷脂酶5（cGMP PDE5）功能的疾病。

  公开号：

  US07741483B2
• 作为产物：
  描述：

  2-氨基-4-甲基-1-丙基-1H-吡咯-3-甲腈 、 2-乙氧基苯甲酸 以41的产率得到N-(3-cyano-4-methyl-1-n-propyl-1H-pyrrol-2-yl)-2-ethoxylbenzamide
  参考文献：
  名称：

  Process for making substituted pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of phosphodiesterase 5

  摘要：

  本发明涉及公式I的化合物，其制备方法以及含有该化合物的制药组合物。本发明还涉及使用公式I的化合物制备药物，可以治疗动物（包括人类（男性和女性））的性功能障碍，尤其是男性勃起功能障碍和涉及磷脂酶5（cGMP PDE5）功能的疾病。

  公开号：

  US07741483B2

文献信息

• Process for making substituted pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of phosphodiesterase 5
  申请人：Yangtze River Pharmaceutical (Group) Co., Ltd.

  公开号：US07741483B2

  公开（公告）日：2010-06-22

  The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.

  本发明涉及公式I的化合物，其制备方法以及含有该化合物的制药组合物。本发明还涉及使用公式I的化合物制备药物，可以治疗动物（包括人类（男性和女性））的性功能障碍，尤其是男性勃起功能障碍和涉及磷脂酶5（cGMP PDE5）功能的疾病。
• 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE[2,3-D]PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF
  申请人：Tianjin Tasly Group Co., Ltd.

  公开号：EP1634883A1

  公开（公告）日：2006-03-15

  The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.

  本发明涉及式 I 化合物、其制备方法以及含有该化合物的药物组合物。本发明还涉及式 I 化合物在制备药物中的用途，这些药物可治疗包括人类（雄性和雌性）在内的动物的性功能障碍，尤其是雄性动物的勃起功能障碍以及磷脂酶 5（cGMP PDE5）功能参与的疾病。
• 2-Substituted phenyl-5,7-dialkyl-3,7-dihydropyrrole [2,3-d]pyrimidine-4-one derivatives, the preparation and the pharmaceutical use thereof
  申请人：Wang Yongfeng

  公开号：US20060173025A1

  公开（公告）日：2006-08-03

  The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.

  本发明涉及式 I 化合物、其制备方法以及含有该化合物的药物组合物。本发明还涉及式 I 化合物在制备药物中的用途，这些药物可治疗包括人类（雄性和雌性）在内的动物的性功能障碍，尤其是雄性动物的勃起功能障碍以及磷脂酶 5（cGMP PDE5）功能参与的疾病。
• 2-SUBSTITUTED PHENYL-5,7-DIALKYL-3,7-DIHYDROPYRROLE[2,3-D] PYRIMIDINE-4-ONE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF
  申请人：Yangtze River Pharmaceutical Group Co., Ltd.

  公开号：EP1634883B1

  公开（公告）日：2010-12-15
• 2-substituted phenyl-5, 7-dehydrocarbyl-3, 7-dihydropyrrolo [2, 3-d] pyrimidin-4-one derivatives, the preparation and the pharmaceutical use thereof
  申请人：Wang Yongfeng

  公开号：US20080167462A1

  公开（公告）日：2008-07-10

  The invention relates to the compounds of formula I, their preparation and the pharmaceutical compositions containing the compounds. The invention also relates to the use of the compounds of formula I in preparing medicines, which can treat sexual dysfunction of animals including human (male and female), especially erectile dysfunction of male and the diseases in which the function of phospholipase 5 (cGMP PDE5) is involved.