Didocosyl benzene-1,2-dicarboxylate | 85401-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Didocosyl benzene-1,2-dicarboxylate
• CAS: 85401-79-2
• 化学式: C₅₂H₉₄O₄
• 分子量: 783.3
• InChiKey: BCPRSOJNDLWHRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  24.2
• 重原子数：
  56
• 可旋转键数：
  46
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• External Preparation Containing NSAIDs And Method For Producing The External Preparation
  申请人：Tei Yuichi

  公开号：US20120135955A1

  公开（公告）日：2012-05-31

  Disclosed is an external preparation containing nonsteroidal anti-inflammatory drugs (NSAIDs), which is suppressed in cytotoxicity induced by the NSAIDs. Also disclosed is a method for producing the external preparation. The present invention is based on the finding that skin disorders induced by nonsteroidal anti-inflammatory drugs (NSAIDs) can be suppressed when the NSAIDs form intermolecular compounds together with trehalose, which is an example of disaccharides. A disaccharide other than trehalose may be used therefor.

  本发明涉及一种含有非甾体抗炎药（NSAIDs）的外用制剂，该制剂被抑制了由NSAIDs引起的细胞毒性。同时还公开了一种制备该外用制剂的方法。本发明基于以下发现：当NSAIDs与双糖中的海藻糖等分子形成分子间化合物时，可以抑制由NSAIDs引起的皮肤疾病。因此，本发明中也可以使用海藻糖以外的其他双糖。
• External Preparation Containing NSAIDS And Method For Producing The External Preparation
  申请人：Next21 K.K.

  公开号：US20140336144A1

  公开（公告）日：2014-11-13

  Disclosed is an external preparation containing nonsteroidal anti-inflammatory drugs (NSAIDs), which is suppressed in cytotoxicity induced by the NSAIDs. Also disclosed is a method for producing the external preparation. The present invention is based on the finding that skin disorders induced by nonsteroidal anti-inflammatory drugs (NSAIDs) can be suppressed when the NSAIDs form intermolecular compounds together with trehalose, which is an example of disaccharides. A disaccharide other than trehalose may be used therefor.

  本发明涉及一种含有非甾体类抗炎药（NSAIDs）的外用制剂，该制剂能够抑制NSAIDs诱导的细胞毒性。同时，本发明还涉及一种制备该外用制剂的方法。本发明基于以下发现：当NSAIDs与二糖之一的海藻糖形成分子间化合物时，可以抑制NSAIDs引起的皮肤疾病。因此，也可以使用其他二糖。
• EXTERNAL PREPARATION CONTAINING NSAIDs AND METHOD FOR PRODUCING THE EXTERNAL PREPARATION
  申请人：Next 21 K.K.

  公开号：EP2457566A1

  公开（公告）日：2012-05-30

  Disclosed is an external preparation containing nonsteroidal anti-inflammatory drugs (NSAIDs), which is suppressed in cytotoxicity induced by the NSAIDs. Also disclosed is a method for producing the external preparation. The present invention is based on the finding that skin disorders induced by nonsteroidal anti-inflammatory drugs (NSAIDs) can be suppressed when the NSAIDs form intermolecular compounds together with trehalose, which is an example of disaccharides. A disaccharide other than trehalose may be used therefor.

  本发明公开了一种含有非甾体抗炎药（NSAIDs）的外用制剂，它能抑制 NSAIDs 诱导的细胞毒性。还公开了一种生产该外用制剂的方法。本发明基于以下发现：当非甾体抗炎药（NSAIDs）与曲哈糖（双糖的一个例子）一起形成分子间化合物时，可抑制由非甾体抗炎药（NSAIDs）诱发的皮肤疾病。为此，可以使用除曲哈琉糖以外的二糖。