5-(4-Hydroxybutynyl)uridine | 85267-67-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-(4-Hydroxybutynyl)uridine
• 英文别名: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(4-hydroxybut-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione；1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(4-hydroxybut-1-ynyl)pyrimidine-2,4-dione
• CAS: 85267-67-0
• 化学式: C₁₃H₁₆N₂O₇
• 分子量: 312.279
• InChiKey: JOODRRAZXIYEBW-DNRKLUKYSA-N

物化性质

• 密度：
  1.65±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  140
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(4-Hydroxybutynyl)uridine 在 mercury(II) sulfate 作用下， 以 水 为溶剂， 反应 2.0h， 生成 5-(4-Hydroxybutanoyl)uridine
  参考文献：
  名称：

  Nucleic acid related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides

  摘要：

  DOI：

  10.1021/jo00159a012
• 作为产物：
  描述：

  2',3',5'-Tri-O-p-toluyl-5-<4-(p-toluyloxy)butynyl>uridine 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以81%的产率得到5-(4-Hydroxybutynyl)uridine
  参考文献：
  名称：

  Nucleic acid related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides

  摘要：

  DOI：

  10.1021/jo00159a012

文献信息

• [EN] DUPLEX STABILIZING FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES<br/>[FR] EXTINCTEURS DE FLUORESCENCE STABILISANT LES DUPLEX POUR SONDES NUCLÉIQUES
  申请人：ELITECHGROUP INC

  公开号：WO2019036225A1

  公开（公告）日：2019-02-21

  Diaryl-azo derivatives are efficient fluorescence quenchers as well as nucleic acid duplex-stabilizing agents and are useful in oligonucleotide conjugates and probes. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.

  二苯基偶氮衍生物既是高效的荧光猝灭剂，又是核酸双链稳定剂，在寡核苷酸共轭物和探针中具有用途。寡核苷酸-猝灭剂共轭物可用于核酸靶标的检测方法中。
• HYPERTHEROMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE
  申请人：Belousov Yevgeniy

  公开号：US20110151457A1

  公开（公告）日：2011-06-23

  The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism.

  本发明涉及一种高温稳定的内切酶IV底物探针，用于核酸检测方法，该方法可以使用高温稳定酶进行，包括检测目标核酸和检测核酸多态性。
• HYPERTHERMOSTABLE ENDONUCLEASE IV SUBSTRATE PROBE
  申请人：Belousov Yevgeniy

  公开号：US20130022976A1

  公开（公告）日：2013-01-24

  The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism.

  本发明涉及一种高温稳定的内切酶IV底物探针，用于核酸检测方法中，可以使用高温稳定酶进行检测目标核酸和检测核酸多态性。
• Methods for true isothermal strand displacement amplification
  申请人：ELITechGroup, Inc.

  公开号：US10590474B2

  公开（公告）日：2020-03-17

  Methods, primers and probes are provided for the isothermal amplification and detection, without denaturation, of double stranded nucleic acid targets for polymerase strand displacement amplification (“iSDA”). The methods and compositions disclosed are highly specific for nucleic acid targets with high sensitivity, specificity and speed that allow detection of clinical relevant target levels. The methods and compositions can easily be used to amplify or detect nucleic acid targets in biological samples.

  提供了用于聚合酶链位移扩增（"iSDA"）的双链核酸靶标的等温扩增和检测方法、引物和探针，无需变性。所公开的方法和组合物对核酸靶标具有高度特异性，灵敏度高、特异性强、速度快，可检测临床相关的靶标水平。这些方法和组合物可轻松用于扩增或检测生物样本中的核酸靶标。
• Duplex stabilizing fluorescence quenchers for nucleic acid probes
  申请人：ELITechGroup, Inc.

  公开号：US10677728B2

  公开（公告）日：2020-06-09

  Diaryl-azo derivatives are efficient fluorescence quenchers as well as nucleic acid duplex-stabilizing agents and are useful in oligonucleotide conjugates and probes. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.

  二芳基偶氮衍生物是高效的荧光淬灭剂和核酸双链稳定剂，可用于寡核苷酸共轭物和探针。寡核苷酸淬灭剂共轭物可用于核酸靶标的检测方法。