4-Methoxy-2-methylamino-pyrimidin | 66131-71-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Methoxy-2-methylamino-pyrimidin
• 英文别名: 4-methoxy-N-methylpyrimidin-2-amine
• CAS: 66131-71-3
• 化学式: C₆H₉N₃O
• mdl: MFCD09054909
• 分子量: 139.157
• InChiKey: OPBJFWASRUHSHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  47
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL FUSED PYRROLOCARBAZOLES<br/>[FR] NOUVEAUX PYRROLOCARBAZOLES FONDUS
  申请人：CEPHALON INC

  公开号：WO2005063763A1

  公开（公告）日：2005-07-14

  The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.

  本发明涉及选定的融合吡咯烷基咔唑，包括其医药组合物及用于治疗疾病的方法。本发明还涉及中间体和制备这些融合吡咯烷基咔唑的方法。
• THERAPEUTIC OR PROPHYLACTIC AGENT FOR ALLERGIC DERMATITIS
  申请人：Kaino Mie

  公开号：US20090093508A1

  公开（公告）日：2009-04-09

  A therapeutic or prophylactic agent for allergic dermatitis is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for allergic dermatitis according to the present invention has high therapeutic or prophylactic effect.

  本发明揭示了一种用于过敏性皮炎的治疗或预防剂。该治疗或预防剂包括作为有效成分的一种具有特定结构的甘氨酸衍生物或其药学上可接受的盐，例如下述化合物[(E)-2-(2,6-二氯苯甲酰胺)-5-[4-(异丙基嘧啶-2-基)苯基]戊-4-烯酸]。本发明所述的过敏性皮炎治疗或预防剂具有高度的治疗或预防效果。
• IMIDAZO[1,2-a]PYRIDINE COMPOUNDS
  申请人：Fang Qun Kevin

  公开号：US20110166146A1

  公开（公告）日：2011-07-07

  Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.

  本发明揭示了咪唑并[1,2-a]吡啶类化合物。该发明的化合物是有用的治疗剂，揭示了它们在制药配方中的包含以及在治疗方法中的使用。
• 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS
  申请人：Cole Andrew G.

  公开号：US20110230480A1

  公开（公告）日：2011-09-22

  Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.

  本发明揭示了式为的化合物，其为Mnk2抑制剂，可用于治疗和预防代谢性疾病，如肥胖症和糖尿病。
• Pyrazolopyridine, Pyrazolopyrazine, Pyrazolopyrimidine, Pyrazolothiophene and Pyrazolothiazole Compounds as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction
  申请人：Conn P. Jeffrey

  公开号：US20130065895A1

  公开（公告）日：2013-03-14

  Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

  Pyrazolopyridine，pyrazolopyrazine，pyrazolopyrimidine，pyrazolothiophene和pyrazolothiazole化合物，可作为代谢型谷氨酸受体亚型4（mGluR4）的变构势增强剂/正变构调节剂；制备这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物的方法，例如用于治疗神经和精神障碍或与谷氨酸功能障碍相关的其他疾病状态。