2,4-Di-t-butyl-6-isopropyl-phenol | 22354-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Di-t-butyl-6-isopropyl-phenol
• 英文别名: 2-Isopropyl-4,6-di-tert-butylphenol；2,4-DI-T-Butyl-6-isopropylphenol；2,4-ditert-butyl-6-propan-2-ylphenol
• CAS: 22354-52-5
• 化学式: C₁₇H₂₈O
• 分子量: 248.409
• InChiKey: PCEGJZYQXAYULP-UHFFFAOYSA-N

物化性质

• 沸点：
  284.7±9.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• 2,3-dihydrobenzofuran derivatives
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20020156296A1

  公开（公告）日：2002-10-24

  2,3-Dihydrobenzofuran derivatives of general formula 1 wherein R 1 represents a hydrogen atom or an acyl group; R 2 , R 3 and R 4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R 5 and R 6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or sulfur atoms, provided that R 2 and R 3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.

  通式1的2,3-二氢苯并呋喃衍生物，其中R1代表氢原子或酰基；R2、R3和R4代表氢原子、低碳烷基或低碳烯基；R5和R6结合形成环戊基或含有一个或多个氧原子或硫原子的饱和杂环基团，但R2和R3不能同时代表叔丁基基团，或其光学异构体或药学上可接受的盐可用作各种肾脏疾病的治疗或预防剂以及器官保护剂。
• 2,3-DIHYDROBENZOFURAN DERIVATIVES
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP0995437A1

  公开（公告）日：2000-04-26

  2,3-Dihydrobenzofuran derivatives of general formula (1): wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R5 and R6 represent a hydrogen atom or an optionally substituted alkyl group, or R5 and R6 combine to form a cycloalkyl group or a saturated heterocyclic group containing one or more oxygen atoms or alkyl-substituted nitrogen atoms, provided that R2 and R3 can not simultaneously represent a t-butyl group, or optically active isomers or pharmaceutically acceptable salts thereof are useful as therapeutic or prophylactic agents for various renal diseases and as organ preservatives.

  通式(1)的 2,3-二氢苯并呋喃衍生物： 其中 R1 代表氢原子或酰基；R2、R3 和 R4 代表氢原子、低级烷基或低级烯基；R5 和 R6 代表氢原子或任选取代的烷基，或 R5 和 R6 结合形成环烷基或含有一个或多个氧原子或烷基取代的氮原子的饱和杂环基，但 R2 和 R3 不能同时代表叔丁基，或其光学活性异构体或药学上可接受的盐，可用作各种肾脏疾病的治疗剂或预防剂以及器官防腐剂。
• 1,2-ALKANE POLYOL-CONTAINING COMPOSITION
  申请人：Osaka Organic Chemical Ind., Ltd.

  公开号：EP2985017A1

  公开（公告）日：2016-02-17

  Provided is a composition containing, as an alkane polyol, a C4-18 1,2-alkane polyol in which the degradation over time of the C4-18 1,2-alkane polyol, which has inferior chemical stability and degrades easily, is suppressed, the composition being suitable for use in a cosmetic, an inkjet ink, a fiber or a coating material such as a paint. A composition containing 1,2-alkane polyol that can be used in a cosmetic, an inkjet ink, a raw material for fibers or a coating material, the alkane polyol being a C4-18 1,2-alkane polyol, and the composition containing a radical scavenger.

  本发明提供了一种含有 C4-18 1,2-烷烃多元醇作为烷烃多元醇的组合物，在该组合物中，化学稳定性较差且容易降解的 C4-18 1,2-烷烃多元醇随时间推移的降解受到抑制，该组合物适用于化妆品、喷墨墨水、纤维或涂料等涂层材料。一种含有 1,2-烷烃多元醇的组合物，可用于化妆品、喷墨墨水、纤维原料或涂层材料，烷烃多元醇为 C4-18 1,2-烷烃多元醇，组合物中含有自由基清除剂。
• COMPOSITIONS AND METHODS OF TREATING CHRONIC PAIN BY ADMINISTERING PROPOFOL DERIVATIVES
  申请人：Tibbs Gareth R.

  公开号：US20130005718A1

  公开（公告）日：2013-01-03

  Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof an effective amount of propofol or a propofol derivative having limited anesthetic properties. Methods of modulating HCN channel gating are also provided. Pharmaceutically acceptable compositions for, e.g., modulating HCN channel gating are further provided.
• CHIRAL DIAMINE COMPOUNDS FOR THE PREPARATION OF CHIRAL ALCOHOLS AND CHIRAL AMINES
  申请人：University College Dublin

  公开号：US20170204036A1

  公开（公告）日：2017-07-20

  A process for the stereoselective preparation of a chiral alcohol or a chiral amine, the process comprising reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant comprising a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein: Also provided is the use of the chiral trans-diamine of formula (1) in a Grignard reaction and the chiral trans-diamines per se.