5-[2-(3,4-dichlorophenyl)ethylamino]-2-hydroxybenzoic acid | 952498-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[2-(3,4-dichlorophenyl)ethylamino]-2-hydroxybenzoic acid
• CAS: 952498-32-7
• 化学式: C₁₅H₁₃Cl₂NO₃
• 分子量: 326.179
• InChiKey: NELHLGXTKKBRCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Methyl 2-acetyloxy-5-[2-(3,4-dichlorophenyl)ethylamino]benzoate 在 盐酸 、 溶剂黄146 作用下， 反应 6.0h， 以94%的产率得到5-[2-(3,4-dichlorophenyl)ethylamino]-2-hydroxybenzoic acid
  参考文献：
  名称：

  A New Route of Synthesis of 5‐(N‐Phenethylamino)salicylic Acid Derivatives by Rapid and Selective Reduction of the Amide Group with NaBH₄/Acetic Acid

  摘要：

  A good yield of 5-(N-phenethylamino)salicylic acid derivatives was successfully obtained from the corresponding methyl 2-acetoxy-5-(N-phenethylamino)benzoate esters by rapid and selective reduction of the amide group in the acyl protected salicylic acid with NaBH(4)/acetic acid in dioxane followed by hydrolysis of the ester group.

  DOI：

  10.1080/00397910801982001

文献信息

• Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases
  申请人：GWAG Byoung-Joo

  公开号：US20090240079A1

  公开（公告）日：2009-09-24

  The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

  本发明涉及一种用于治疗或预防炎症性疾病和细胞损伤的药物组合物，以及一种用于治疗或预防炎症性疾病和细胞损伤的方法。本发明使用由特定化学式表示的2-羟基苯甲酸衍生物或其药用可接受的盐。本发明的化合物对治疗或预防包括胃炎、胃溃疡、胰腺炎、结肠炎、关节炎、糖尿病、动脉硬化、肾炎、肝炎、阿尔茨海默病、帕金森病和路易·盖里格病在内的细胞损伤和炎症性疾病有益。
• COSMETIC COMPOSITION COMPRISING 5-BENZYLAMINOSALICYLIC ACID DERIVATIVE AND LOCAL ADMINISTRATION METHOD THEREOF
  申请人：GNT Pharma Co., Ltd

  公开号：EP3998058A1

  公开（公告）日：2022-05-18

  The present invention relates to a composition comprising: a 5-benzyl aminosalicylic acid compound in chemical formula I or cosmetically acceptable salts thereof; and a cosmetically acceptable excipient suitable for local administration. The composition comprising the 5-benzyl aminosalicylic acid compound in chemical formula I or cosmetically acceptable salts thereof can be used for reducing or alleviating human skin aging by means of antioxidant, anti-inflammatory and whitening actions on the skin.

  本发明涉及一种组合物，该组合物包含：化学式 I 中的 5-苄基氨基水杨酸化合物或其美容上可接受的盐；以及适用于局部给药的美容上可接受的赋形剂。由化学式 I 中的 5-苄基氨基水杨酸化合物或其化妆品可接受盐组成的组合物可通过抗氧化、消炎和美白作用减少或缓解人体皮肤老化。
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Neurotech Co., Ltd.

  公开号：EP2004164A1

  公开（公告）日：2008-12-24
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING INFLAMMATORY DISEASES
  申请人：Neurotech Pharmaceuticals Co., Ltd.

  公开号：EP2004164B1

  公开（公告）日：2018-08-08
• Medical use of 5-benzylamino salicylic acid derivatives or salts thereof
  申请人：Neurotech Pharmaceuticals Co., Ltd.

  公开号：EP2394645B1

  公开（公告）日：2014-10-08