1-(2-Prop-2-enylphenyl)but-3-en-1-ol | 1073174-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Prop-2-enylphenyl)but-3-en-1-ol
• CAS: 1073174-98-7
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: FUEJSPVUMYHBFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以83.5 mg的产率得到1-(2-Prop-2-enylphenyl)but-3-en-1-ol
  参考文献：
  名称：

  Ortho-TMS 苯甲醛：II 型阴离子中继化学 (ARC) 的有效关键。

  摘要：

  Ortho-TMS benzaldehyde, an effective bifunctional linchpin for Type II Anion Relay Chemistry (ARC), permits efficient multi-component union of a variety of nucleophiles and electrophiles, including the first example of a Pd-mediated ARC Type II process. To demonstrate the utility of the Type II ARC protocol, a “proof of concept” synthetic sequence was designed and implemented for construction of a focused library of “natural product-like” compounds.

  DOI：

  10.1002/anie.200802301

文献信息

• Palladium/ClickFerrophos-Catalyzed Asymmetric Domino Allylstannylation–Heck Reaction of <i>o</i>-Formylaryl Triflate
  作者：Atsuo Tada、Yuichiro Tokoro、Shin-ichi Fukuzawa

  DOI：10.1021/jo5010247

  日期：2014.9.5

  Asymmetric domino allylstannylation-Heck reaction of o-formylaryl triflates was successively catalyzed by Pd/ClickFerrophos to give the 3-methylene-indan-1-ols in good yields with good to excellent enantioselectivities. The benefit of the reaction is that the starting o-formylaryl triflates are prepared from easily accessible salicylaldehyde derivatives, and the variation of the product, chiral 3-methylene-indan-1-ols, can be expanded. The reaction with 4-substituted substrates gave the corresponding 3-methylene-indan-1-ols in good yields with high enantioselectivities, whereas the reaction with 5- and 6-substituted substrates occasionally afforded the corresponding Stille coupling product in significant amounts along with the desired 3-methylene-indan-1-ols.
• <i>Ortho</i>-TMS Benzaldehyde: An Effective Linchpin for Type II Anion Relay Chemistry (ARC)
  作者：Amos B. Smith、Won-Suk Kim、William M. Wuest

  DOI：10.1002/anie.200802301

  日期：2008.9.1

  Ortho-TMS benzaldehyde, an effective bifunctional linchpin for Type II Anion Relay Chemistry (ARC), permits efficient multi-component union of a variety of nucleophiles and electrophiles, including the first example of a Pd-mediated ARC Type II process. To demonstrate the utility of the Type II ARC protocol, a “proof of concept” synthetic sequence was designed and implemented for construction of a focused library of “natural product-like” compounds.