2-Methyl-4-(trifluoromethyl)benzamide | 1214323-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-4-(trifluoromethyl)benzamide
• CAS: 1214323-24-6
• 化学式: C₉H₈F₃NO
• 分子量: 203.16
• InChiKey: MRDNOEMCHQZIMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase
  申请人：Lehr Philipp

  公开号：US20090042899A1

  公开（公告）日：2009-02-12

  Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steroid sulfatase.

  哌嗪基或哌啶基氨基磺酸酰胺及其用于制备治疗由类固醇磺酸酯酶介导的疾病药物。
• AMINE LINKED MODULATORS OF Y-SECRETASE
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2212277A1

  公开（公告）日：2010-08-04
• US7439362B2
  申请人：——

  公开号：US7439362B2

  公开（公告）日：2008-10-21
• [EN] 1,4-DIARYL-1-CYCLOPROPYL-4-SUBSTITUTED BUTANES AS INSECTICIDES AND ACARICIDES
  申请人：FMC CORPORATION

  公开号：WO1993001715A1

  公开（公告）日：1993-02-04

  (EN) The 1,4-diaryl-1-cyclopropyl-4-substituted butane pesticides of formula (I) are effective as insecticides and acaricides in which X and Y are independently hydrogen, halogen, alkyl, alkoxy, cycloalkylalkoxy, alkylcarbonyl, alkoxycarbonyl, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, alkylsulfonyl, trialkylamino, nitro, or cyano; or X and Y together are -OCH2O- or -OCF2O- bridging the 2-3 or 3-4 positions of the phenyl ring; Ar is 3-phenoxyphenyl, 4-fluoro-3-phenoxyphenyl, 6-phenoxypyridin-2-yl, or 2-methyl(1,1'-biphenyl)-3-yl; R is cyano, methyl, trifluoromethyl, alkenyl, alkynyl or halogen.(FR) Pesticides de butane à substitution 1,4-diaryl-1-cyclopropyl-4 de la formule (I), utiles comme insecticides et acaricides, dans laquelle X et Y sont indépendamment hydrogène, halogène, alkyle, arkoxy, cycloalkylalkoxy, alkylcarbonyle, alkoxycarbonyle, haloalkyle, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyle, alkylsulfonyle, trialkylamino, nitro, ou cyano; ou X et Y ensemble sont -OCH2O- ou -OCF2O- établissant un pont avec les positions 2-3 ou 3-4 de l'anneau phényle; Ar est 3-phénoxyphényle, 4-fluoro-3-phénoxyphényle, 6-phénoxypyridin-2-yle, ou 2-méthyl(1,1'-biphényle)-3-yle; R est cyano, méthyle, trifluorométhyle, alkényle, alkynyle, ou halogène.
• [EN] AMINE LINKED MODULATORS OF Y-SECRETASE<br/>[FR] MODULATEURS DE LA G-SECRÉTASE LIÉS À UNE AMINE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009052350A1

  公开（公告）日：2009-04-23

  The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with y-secretase activity, including Alzheimer´s disease.