N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]benzamide | 1191940-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]benzamide
• CAS: 1191940-74-5
• 化学式: C₁₅H₁₁F₃N₂O
• 分子量: 292.26
• InChiKey: IHWQVOZQVBWUKL-VXLYETTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(苯甲酰基)吡咯烷-2-酮 在 一水合肼 作用下， 以 水 为溶剂， 反应 0.08h， 生成 N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]benzamide
  参考文献：
  名称：

  由活化酰胺合成酰肼和腙

  摘要：

  开发了酰肼和酰腙的合成方法。它们涉及活化酰胺与肼在无过渡金属催化剂的条件下的反应。此外，通过在醛（或酮）存在下扩展相同的反应程序来合成酰基腙。这些反应在 25 °C 的水性环境中进行，证明以高产率成功获得了所需化合物。

  DOI：

  10.1055/a-2270-0518

文献信息

• Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus
  作者：Thaís Moreira Osório、Franco Delle Monache、Louise Domeneghini Chiaradia、Alessandra Mascarello、Taisa Regina Stumpf、Carlos Roberto Zanetti、Douglas Bardini Silveira、Célia Regina Monte Barardi、Elza de Fatima Albino Smânia、Aline Viancelli、Lucas Ariel Totaro Garcia、Rosendo Augusto Yunes、Ricardo José Nunes、Artur Smânia

  DOI：10.1016/j.bmcl.2011.11.059

  日期：2012.1

  The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies. (C) 2011 Elsevier Ltd. All rights reserved.