Dextromethorphan hydrate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Dextromethorphan hydrate
• 英文别名: (1R,9R,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene;hydrate;hydrobromide
• 化学式: C18H28BrNO2
• 分子量: 370.3
• InChiKey: STTADZBLEUMJRG-NPTCXNBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.14
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  13.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Methods and compositions for deterring abuse of orally administered pharmaceutical products
  申请人：Emigh F. James

  公开号：US20070231268A1

  公开（公告）日：2007-10-04

  This invention relates to an abuse deterrent formulation of an oral dosage form of a therapeutically effective amount of any active drug substance that can be subject to abuse combined with a gel forming polymer, a nasal mucosal irritating surfactant and a flushing agent. Such a dosage form is intended to deter abuse of the active drug substance via injection, nasal inhalation or consumption of quantities of the dosage unit exceeding the usual therapeutically effective dose.
• Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders
  申请人：Billstein Anthony Stephan

  公开号：US20080090878A1

  公开（公告）日：2008-04-17

  The present invention relates to a combination of a first agent including either a 5-HT 4 receptor agonist or antagonist or a 5-HT 3 receptor antagonist and a co-agent and pharmaceutical compositions and formulations containing the combination. The present invention also relates to a method of treating a gastrointestinal and abdominal viscera disorder by administering the pharmaceutical compositions to a patient. The pharmaceutical compositions may also be employed as laxatives, to prepare a patient for colonoscopy and to regulate and stabilize enterochromaffin cell secretory, pain and motility mechanisms, afferent fiber activity and GI and lower abdominal smooth muscle cells. The dosage is preferably oral and administration is preferably once or twice a day. The preferred first agent is tegaserod.
• COMBINED ADMINISTRATION OF BENZONATATE AND GUAIFENESIN
  申请人：Heck Thomas

  公开号：US20080176955A1

  公开（公告）日：2008-07-24

  Pharmaceutical compositions are provided containing a combination of benzonatate and guaifenesin, or pharmaceutically acceptable salts thereof. Methods of using compositions comprising benzonatate and guaifenesin, or pharmaceutically acceptable salts thereof, provide relief from cough, pulmonary congestion or both. The compositions and methods provide relief to opiate-sensitive individuals, in particular, as well as to infants and other pediatric patients.
• MODIFIED RELEASE LIQUID PHARMACEUTICAL COMPOSITION COMPRISING BROMOPHENIRAMINE, PSEUDOEPHEDRINE AND DEXTROMETHORPHAN
  申请人：WOCKHARDT LIMITED

  公开号：US20150056288A1

  公开（公告）日：2015-02-26

  There is provided a modified release liquid pharmaceutical composition comprising combination of dextromethorphan, bromrpheniramine and pseudoephedrine or pharmaceutically acceptable salts thereof. The invention further provides process for preparation of such compositions.