(1S,9R,10S)-3-hydroxy-4,12-dimethoxy-17-methyl-17-azoniatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one;chloride

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,9R,10S)-3-hydroxy-4,12-dimethoxy-17-methyl-17-azoniatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one;chloride
• 化学式: C19H24ClNO4
• 分子量: 365.8
• InChiKey: YMEVIMJAUHZFMW-LZNSSFOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof
  申请人：Hsu John

  公开号：US10004749B2

  公开（公告）日：2018-06-26

  The present disclosure provides a safe method for anesthesia or the treatment of pain by safely administering an amount of active agent to a patient while reducing the incidence or severity of suppressed respiration. The present disclosure provides a pharmaceutical composition comprising a therapeutic agent and a chemoreceptor respiratory stimulant. In one aspect, the compositions oppose effects of respiratory suppressants by combining a chemoreceptor respiratory stimulant with an opioid receptor agonist or other respiratory-depressing drug. The combination of the two chemical agents, that is, the therapeutic agent and the respiratory stimulant, may be herein described as the “drugs.” The present compositions may be used to treat acute and chronic pain, sleep apnea, and other conditions, leaving only non-lethal side effects.

  本公开提供了一种安全的麻醉或疼痛治疗方法，通过安全地向患者施用一定量的活性剂，同时降低呼吸抑制的发生率或严重程度。本公开提供了一种药物组合物，它包含一种治疗剂和一种化学感受器呼吸兴奋剂。在一个方面，该组合物通过将化学感受器呼吸兴奋剂与阿片受体激动剂或其他呼吸抑制药物相结合来对抗呼吸抑制剂的作用。两种化学制剂的组合，即治疗剂和呼吸兴奋剂，在此可称为 "药物"。本组合物可用于治疗急性和慢性疼痛、睡眠呼吸暂停和其他病症，只留下不致命的副作用。
• COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF
  申请人：Hsu, John

  公开号：EP3324975A1

  公开（公告）日：2018-05-30
• Composition Comprising a Therapeutic Agent and a Respiratory Stimulant and Methods for the Use Thereof
  申请人：Hsu John

  公开号：US20170020885A1

  公开（公告）日：2017-01-26

  The present disclosure provides a safe method for anesthesia or the treatment of pain by safely administering an amount of active agent to a patient while reducing the incidence or severity of suppressed respiration. The present disclosure provides a pharmaceutical composition comprising a therapeutic agent and a chemoreceptor respiratory stimulant. In one aspect, the compositions oppose effects of respiratory suppressants by combining a chemoreceptor respiratory stimulant with an opioid receptor agonist or other respiratory-depressing drug. The combination of the two chemical agents, that is, the therapeutic agent and the respiratory stimulant, may be herein described as the “drugs.” The present compositions may be used to treat acute and chronic pain, sleep apnea, and other conditions, leaving only non-lethal side effects.
• [EN] COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF<br/>[FR] COMPOSITION COMPRENANT UN AGENT THÉRAPEUTIQUE ET UN STIMULANT RESPIRATOIRE, ET PROCÉDÉ D'UTILISATION ASSOCIÉ
  申请人：HSU JOHN

  公开号：WO2017015309A1

  公开（公告）日：2017-01-26

  The present disclosure provides a safe method for anesthesia or the treatment of pain by safely administering an amount of active agent to a patient while reducing the incidence or severity of suppressed respiration. The present disclosure provides a pharmaceutical composition comprising a therapeutic agent and a chemoreceptor respiratory stimulant. In one aspect, the compositions oppose effects of respiratory suppressants by combining a chemoreceptor respiratory stimulant with an opioid receptor agonist or other respiratory-depressing drug. The combination of the two chemical agents, that is, the therapeutic agent and the respiratory stimulant, may be herein described as the "drugs." The present compositions may be used to treat acute and chronic pain, sleep apnea, and other conditions, leaving only non-lethal side effects.