1-[2-{4-(3-pyridyl)-1(2H)-phthalazinon-2-yl}-4-pyridyl]-2,3-bis(hydroxymethyl)-6,7-diethoxynaphthalene hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[2-{4-(3-pyridyl)-1(2H)-phthalazinon-2-yl}-4-pyridyl]-2,3-bis(hydroxymethyl)-6,7-diethoxynaphthalene hydrochloride
• 英文别名: 2-[4-[6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl]pyridin-2-yl]-4-pyridin-1-ium-3-ylphthalazin-1-one;chloride
• 化学式: C₃₄H₃₀N₄O₅*ClH
• 分子量: 611.097
• InChiKey: FGOKXANRQGVLTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.87
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Combinations comprising antimuscarinic agents and PDE4 inhibitors
  申请人：Laboratorios Almirall, S.A.

  公开号：EP1891974A1

  公开（公告）日：2008-02-27

  A combination which comprises (a) a PDE4 inhibitor and (b) an antagonist of M3 muscarinic receptors which is (3R)-1-phenethyl-3-(9H-xanthene-9-carbonyloxy)-1-azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid.

  一种复方制剂，包括(a)PDE4 抑制剂和(b)M3 肌肽受体拮抗剂，即(3R)-1-苯乙基-3-(9H-氧杂蒽-9-甲酰氧基)-1-氮杂双环[2.2.2]辛烷，其形式为具有阴离子 X 的盐，阴离子 X 是单价或多价酸的药学上可接受的阴离子。
• Naphthalene derivatives, process for the preparation thereof, and intermediates therefor, and pharmaceutical compositions comprising them
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0748805B1

  公开（公告）日：1998-04-08
• METHODS OF INDUCING OVULATION
  申请人：Palmer Stephen

  公开号：US20080293622A1

  公开（公告）日：2008-11-27

  The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulators include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
• COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND PDE4 INHIBITORS
  申请人：Escardo Jordi Gras

  公开号：US20090093503A1

  公开（公告）日：2009-04-09

  A combination which comprises (a) a PDE4 inhibitor and (b) an antagonist of M3 muscarinic receplors which is (3R)-1-phencthyl-3-(9H-xanthene-9carbonyloxy)-1-azoniabicyclo[2.2.2]octanc, in the form of a salt having an anion X, which is a pharmaceutically acceptable anion of a mono or polyvalent acid.
• US5969140A
  申请人：——

  公开号：US5969140A

  公开（公告）日：1999-10-19