5-(1H-benzimidazol-2-yl)-10,10,16,16-tetramethyl-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraen-4-one | 155306-73-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 5-(1H-benzimidazol-2-yl)-10,10,16,16-tetramethyl-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraen-4-one
• CAS: 155306-73-3
• 化学式: C₂₆H₂₇N₃O₂
• 分子量: 413.5
• InChiKey: HQBMTOXZFNIBNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CORE/SHELL-TYPE FLUORESCENT DYE-CONTAINING NANOPARTICLE AND PRODUCTION METHOD OF THE SAME
  申请人：Konica Minolta, Inc.

  公开号：EP3281987A1

  公开（公告）日：2018-02-14

  The present invention provides a method of producing core/shell-type fluorescent dye-containing nanoparticles for immunohistochemical staining or live cell imaging, the method including: the step 1 of polymerizing monomers for thermoplastic resin synthesis in the presence of a fluorescent dye and thereby preparing core particles composed of a thermoplastic resin containing the fluorescent dye; and the step 2 of coating the core particles each with a shell layer composed of a thermosetting resin. By the method of producing fluorescent dye-containing nanoparticles according to the present invention, fluorescent dye-containing nanoparticles having a high brightness, whose dye does not elutes into water, physiological saline, culture medium and the like, can be produced, and the fluorescent dye-containing nanoparticles can be effectively utilized in immunohistochemical staining and live cell imaging.

  本发明提供了一种用于免疫组化染色或活细胞成像的核/壳型含荧光染料纳米颗粒的制备方法，该方法包括：步骤1：在荧光染料存在的情况下，聚合合成热塑性树脂的单体，从而制备由含荧光染料的热塑性树脂组成的核颗粒；步骤2：在每个核颗粒上涂覆由热固性树脂组成的壳层。根据本发明的含荧光染料纳米颗粒的生产方法，可以生产出具有高亮度的含荧光染料纳米颗粒，其染料不会在水、生理盐水、培养基等中洗脱，含荧光染料纳米颗粒可以有效地用于免疫组化染色和活细胞成像。
• Aminocoumarin compound, and aminocoumarin compound-containing resin particles
  申请人：Konica Minolta, Inc.

  公开号：US11434376B2

  公开（公告）日：2022-09-06

  The present invention provides: an aminocoumarin compound having a structure represented by the following formula (1); and an aminocoumarin compound-containing resin particle containing the aminocoumarin compound and a resin particle containing the aminocoumarin compound. In formula (1), Rs each independently represent a hydrogen atom or a methyl group, Q represents a sulfur atom, an oxygen atom, or N—R1, and R1 represents a hydrogen atom or a methyl group. The aminocoumarin compound of the present invention is a fluorescent dye that has a longer excitation wavelength than a conventionally known sulfonated coumarin-based compound and is effectively excited at a wavelength of 475 nm or more, particularly at a wavelength around 500 nm. The aminocoumarin compound of the present invention is a fluorescent dye that is excited, for example, at a wavelength of 475 to 510 nm and can be observed in a green light emission region of 510 to 540 nm using the wavelength characteristic, and can be expected to be suitably utilized in immunostaining or the like.

  本发明提供：具有下式（1）所代表结构的氨基香豆素化合物；以及含有该氨基香豆素化合物的含氨基香豆素化合物树脂颗粒和含有该氨基香豆素化合物的树脂颗粒。式（1）中，Rs 各自独立地代表氢原子或甲基，Q 代表硫原子、氧原子或 N-R1，R1 代表氢原子或甲基。本发明的氨基香豆素化合物是一种荧光染料，其激发波长比传统已知的磺化香豆素基化合物更长，可在 475 纳米或更高波长处有效激发，特别是在 500 纳米左右的波长处。本发明的氨基香豆素化合物是一种在例如 475 至 510 纳米的波长下激发的荧光染料，利用波长特性可观察到 510 至 540 纳米的绿光发射区域，可望适当用于免疫染色或类似用途。
• Photosensitive composition, photosensitive lithography plate and method for producing lithography plate
  申请人：Matsumura Toshiyuki

  公开号：US20070020555A1

  公开（公告）日：2007-01-25

  Disclosed is a light sensitive composition containing a compound A having a group capable of undergoing radical polymerization, a compound B having a group capable of undergoing cationic polymerization, a photopolymerization initiator C, and a polymer binder D, the light sensitive composition being characterized in that the photopolymerization initiator C comprises an iron-arene complex and a halogenated alkyl group-containing compound.
• LIGHT-SENSITIVE LITHOGRAPHIC PRINTING PLATE MATERIAL
  申请人：Furukawa Akira

  公开号：US20110318689A1

  公开（公告）日：2011-12-29

  An object of the present invention is to provide a light-sensitive lithographic printing plate material having high sensitivity, generating no background stain even when development is carried out by using a neutral developing solution having a pH of less than 9, or an alkali developing solution having a pH in the range of 9 to 12, generating no background stain even when the plate is allowed to stand after developing treatment or during printing for a long period of time, and having excellent in printing endurance and ink transfer property, and it is accomplished by a light-sensitive lithographic printing plate material which comprises a support and a photo-curable light-sensitive layer formed thereon, said photo-curable light-sensitive layer contains a polymer synthesized by using at least a compound represented by the following mentioned general formula I: wherein R 1 , R 2 and R 3 each independently represent an alkyl group or an alkoxy group each having 1 to 10 carbon atoms; provided that at least two of R 1 , R 2 and R 3 represent alkoxy groups; and Y 1 represents an alkylene group having 1 to 10 carbon atoms, and having a polymerizable double bond group and at least one of a carboxyl group and a sulfonate group at a side chain.
• AMINOCOUMARIN COMPOUND, AND AMINOCOUMARIN COMPOUND-CONTAINING RESIN PARTICLES
  申请人：Konica Minato, Inc.

  公开号：US20210277250A1

  公开（公告）日：2021-09-09

  The present invention provides: an aminocoumarin compound having a structure represented by the following formula (1); and an aminocoumarin compound-containing resin particle containing the aminocoumarin compound and a resin particle containing the aminocoumarin compound. In formula (1), Rs each independently represent a hydrogen atom or a methyl group, Q represents a sulfur atom, an oxygen atom, or N—R 1 , and R 1 represents a hydrogen atom or a methyl group. The aminocoumarin compound of the present invention is a fluorescent dye that has a longer excitation wavelength than a conventionally known sulfonated coumarin-based compound and is effectively excited at a wavelength of 475 nm or more, particularly at a wavelength around 500 nm. The aminocoumarin compound of the present invention is a fluorescent dye that is excited, for example, at a wavelength of 475 to 510 nm and can be observed in a green light emission region of 510 to 540 nm using the wavelength characteristic, and can be expected to be suitably utilized in immunostaining or the like.