Potassium;2-(4-chlorophenyl)acetate | 42766-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Potassium;2-(4-chlorophenyl)acetate
• CAS: 42766-37-0
• 化学式: C₈H₆ClO₂*K
• 分子量: 208.686
• InChiKey: JPIOHODHOZDFDH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.36
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-甲基邻苯二甲酰亚胺 、 Potassium;2-(4-chlorophenyl)acetate 以 水 、 丙酮 为溶剂， 反应 5.0h， 以29%的产率得到3-(4-chlorobenzyl)-3-hydroxy-2-methylisoindolin-1-one
  参考文献：
  名称：

  Photodecarboxylative benzylations of phthalimides

  摘要：

  Photoadditions of phenylacetates to phthalimides give the corresponding benzylated hydroxyphthalimidines in moderate to high yields of 29-90%. With 2-phenylpropanoate, photoaddition affords a diastereoisomeric mixture in a de of 24% in favour of the like-diastereoisomer. L-3-Phenyl lactate and 2-oxo-3-phenylpropanoate both furnish the benzylated product through subsequent loss of formaldehyde and decarbonylation, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.115
• 作为产物：
  描述：

  对氯苯乙酸 、 氢氧化钾 生成 Potassium;2-(4-chlorophenyl)acetate
  参考文献：
  名称：

  MANOLOV, I.;KARAIVANOVA, M. H.

  摘要：

  DOI：

文献信息

• Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates
  作者：Wei-Long Xing、De-Guang Liu、Ming-Chen Fu

  DOI：10.1039/d1ra00063b

  日期：——

  transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C–Se bonds under the simple and mild reaction

  报道了一种无过渡金属的脱羧硫醇化方案，其中伯、仲、叔（杂）芳基乙酸酯和α-CN 取代的乙酸酯顺利地进行脱羧硫醇化，以中等至优异的产率提供各种功能化的芳基烷基硫化物。芳基二硒化物也是在简单温和的反应条件下构建 C-Se 键的合适底物。此外，该方案成功应用于药物羧酸盐的后期修饰，具有令人满意的化学选择性和官能团相容性。
• Photodecarboxylative Benzylations of N-Methoxyphthalimide under Batch and Continuous-Flow Conditions
  作者：Hossein Mohammadkhani Pordanjani、Christian Faderl、Jun Wang、Cherie A. Motti、Peter C. Junk、Michael Oelgemöller

  DOI：10.1071/ch15356

  日期：——

  A series of photodecarboxylative benzylations of N-methoxyphthalimide were successfully realised using easily accessible starting materials. The reactions proceeded smoothly and the corresponding benzylated hydroxyphthalimidines were obtained in moderate to good yields of 52–73 %. No competing photoinduced dealkoxylation of the N-methoxy group was observed. The reaction with potassium phenylacetate was subsequently investigated in an advanced continuous-flow photoreactor. The reactor allowed rapid optimization of the reaction conditions and gave the desired benzylated product in higher yield and shorter irradiation time compared with the batch process.

  利用容易获得的起始材料，成功实现了一系列 N-甲氧基邻苯二甲酰亚胺的光致十二羧基苄基化反应。反应顺利进行，并获得了相应的苄基羟基邻苯二甲酰亚胺，收率从中等到良好，为 52-73%。没有观察到 N-甲氧基发生竞争性光诱导脱烷氧基化反应。与苯乙酸钾的反应随后在先进的连续流光反应器中进行了研究。与间歇式工艺相比，该反应器可以快速优化反应条件，并以更高的产率和更短的辐照时间得到所需的苄基化产物。
• Photodecarboxylative benzylations of phthalimide in pH 7 buffer: a simple access to 3-arylmethyleneisoindolin-1-ones
  作者：Vincent Belluau、Pierre Noeureuil、Elfrun Ratzke、Aleksei Skvortsov、Sonia Gallagher、Cherri Ann Motti、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2010.07.017

  日期：2010.9

  Photoadditions of phenylacetates to phthalimide in pH 7 buffer solution give the corresponding benzylated-hydroxyphthalimidines in moderate to high yields of up to 94%. In a micro-structured reactor, higher conversions and purities are achieved. With branched phenylacetates, photoaddition affords diastereoisomeric mixtures with low to moderate de values. Subsequent acid-catalyzed dehydration furnishes the corresponding 3-arylmethyleneisoindolin-1-ones in good to excellent yields and with high E-selectivities. Irradiation of the parent 3-phenylmethyleneisoindolin-1-one under oxidative conditions only leads to cis/trans-isomerization. (C) 2010 Elsevier Ltd. All rights reserved.