1-allyl-2,4-difluorobenzene | 951893-28-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-allyl-2,4-difluorobenzene
• 英文别名: 3-(2,4-Difluorophenyl)-1-propene；2,4-difluoro-1-prop-2-enylbenzene
• CAS: 951893-28-0
• 化学式: C₉H₈F₂
• 分子量: 154.159
• InChiKey: UOJLVZAZFAUJGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-allyl-2,4-difluorobenzene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 4-二甲氨基吡啶 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 70.0h， 生成 6-(2,4-difluorophenyl)hex-4-en-2-yl (4-methoxybenzyl) carbonate
  参考文献：
  名称：

  Synthesis of 1,3‐Dioxan‐2‐ones by Photo‐Aerobic Selenium‐π‐Acid Multicatalysis

  摘要：

  AbstractAn expedient method for the synthesis of cyclic carbonates from homoallylic carbonic acid esters by means of photo‐aerobic selenium‐π‐acid multicatalysis is reported. Until now, conceptually related methods commonly relied either on the stoichiometric addition of electrophiles onto the substrate's alkene moiety or the presence of pre‐installed leaving groups in allylic position of said alkene to – in part, catalytically – initiate an intramolecular attack by an adjacent carbonic acid ester group. In sharp contrast, the current study shows that the C−C double bond of homoallylic carbonic acid esters can be directly activated by the catalytic interplay of a pyrylium dye and a diselane using ambient air as the sole oxidant and visible light as an energy source.

  DOI：

  10.1002/ejoc.202201180
• 作为产物：
  描述：

  3-溴丙烯 、 2,4-二氟苯硼酸 在 palladium diacetate 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 以82 %的产率得到1-allyl-2,4-difluorobenzene
  参考文献：
  名称：

  Synthesis of 1,3‐Dioxan‐2‐ones by Photo‐Aerobic Selenium‐π‐Acid Multicatalysis

  摘要：

  AbstractAn expedient method for the synthesis of cyclic carbonates from homoallylic carbonic acid esters by means of photo‐aerobic selenium‐π‐acid multicatalysis is reported. Until now, conceptually related methods commonly relied either on the stoichiometric addition of electrophiles onto the substrate's alkene moiety or the presence of pre‐installed leaving groups in allylic position of said alkene to – in part, catalytically – initiate an intramolecular attack by an adjacent carbonic acid ester group. In sharp contrast, the current study shows that the C−C double bond of homoallylic carbonic acid esters can be directly activated by the catalytic interplay of a pyrylium dye and a diselane using ambient air as the sole oxidant and visible light as an energy source.

  DOI：

  10.1002/ejoc.202201180

文献信息

• [EN] PROSTAGLANDIN TRANSPORTER INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE TRANSPORTEUR DE PROSTAGLANDINE ET LEURS UTILISATIONS
  申请人：EINSTEIN COLL MED

  公开号：WO2011037610A1

  公开（公告）日：2011-03-31

  Disclosed are compounds for inhibiting prostaglandin transporter (PGT) activity, pharmaceuticals compositions including the compounds, and methods of treating subjects using the compounds.

  揭示了用于抑制前列腺素转运体（PGT）活性的化合物，包括这些化合物的药物组合物，以及使用这些化合物治疗受试者的方法。
• Inhibitors of Ion Channels
  申请人：Marron Brian Edward

  公开号：US20130072471A1

  公开（公告）日：2013-03-21

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了在通过抑制电压门控钠通道中的钠离子流来治疗疾病方面有用的化合物、组合物和方法。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，特别是疼痛和慢性疼痛的方法，通过阻断与所示条件的发生或复发相关的钠通道来实现。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子流来治疗神经病性或炎症性疼痛。
• US8741934B2
  申请人：——

  公开号：US8741934B2

  公开（公告）日：2014-06-03
• Synthesis of 1,3‐Dioxan‐2‐ones by Photo‐Aerobic Selenium‐π‐Acid Multicatalysis
  作者：Kilian A. Müller、Carolin H. Nagel、Alexander Breder

  DOI：10.1002/ejoc.202201180

  日期：2023.1.10

  AbstractAn expedient method for the synthesis of cyclic carbonates from homoallylic carbonic acid esters by means of photo‐aerobic selenium‐π‐acid multicatalysis is reported. Until now, conceptually related methods commonly relied either on the stoichiometric addition of electrophiles onto the substrate's alkene moiety or the presence of pre‐installed leaving groups in allylic position of said alkene to – in part, catalytically – initiate an intramolecular attack by an adjacent carbonic acid ester group. In sharp contrast, the current study shows that the C−C double bond of homoallylic carbonic acid esters can be directly activated by the catalytic interplay of a pyrylium dye and a diselane using ambient air as the sole oxidant and visible light as an energy source.