(1S,12S,15R,16R,17R,28R,31S,32S)-6,12,22,28-tetratert-butyl-15,31-bis(4-chlorophenyl)-14,30-diphenyl-2,13,18,29-tetraoxa-14,30-diazanonacyclo[24.6.1.11,4.110,17.117,20.03,8.012,16.019,24.028,32]hexatriaconta-3(8),4,6,10,19(24),20,22,26-octaene-33,35-dione | 1018740-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (1S,12S,15R,16R,17R,28R,31S,32S)-6,12,22,28-tetratert-butyl-15,31-bis(4-chlorophenyl)-14,30-diphenyl-2,13,18,29-tetraoxa-14,30-diazanonacyclo[24.6.1.11,4.110,17.117,20.03,8.012,16.019,24.028,32]hexatriaconta-3(8),4,6,10,19(24),20,22,26-octaene-33,35-dione
• CAS: 1018740-82-3
• 化学式: C₇₀H₇₂Cl₂N₂O₆
• 分子量: 1108.26
• InChiKey: ASLRUFRDUMEUBY-XVXHGXNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.1
• 重原子数：
  80
• 可旋转键数：
  8
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (4-chlorobenzylidene)phenylamine N-oxide 、 2,8,13,19-Tetrakis(1,1-dimethylethyl)-11H,22H-4,6:6,10:15,17:17,21-tetramethanodibenzo<1,10>dioxacyclooctadecin-23,25-dione 以 甲苯 为溶剂， 反应 44.0h， 以99%的产率得到(1S,12S,15R,16R,17R,28R,31S,32S)-6,12,22,28-tetratert-butyl-15,31-bis(4-chlorophenyl)-14,30-diphenyl-2,13,18,29-tetraoxa-14,30-diazanonacyclo[24.6.1.11,4.110,17.117,20.03,8.012,16.019,24.028,32]hexatriaconta-3(8),4,6,10,19(24),20,22,26-octaene-33,35-dione
  参考文献：
  名称：

  Novel 1,3-dipolar cycloaddition reactions of calix[4]bis(spirodienones): synthesis of isoxazolidine derived macrocycles

  摘要：

  Calix [4]bis(spirodienones) can perform as either 4 pi or 2 pi components in cycloaddition reactions with various carbo- and heterodienophiles and with 1,2-benzoquinones leading to the formation of highly functionalized macrocycles. In this Letter we report, highly regio- and stereoselective 1,3-dipolar cycloaddition reactions of a bis(spirodienone) derivative of calix[4]arene with nitrones that provide easy access to isoxazolidine derived macrocycles in excellent yields. These isoxazolidine derivatives can be considered as direct precursors of 1,3-amino alcohols. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.082

文献信息

• Novel 1,3-dipolar cycloaddition reactions of calix[4]bis(spirodienones): synthesis of isoxazolidine derived macrocycles
  作者：V.B. Ganga、E. Suresh、R. Luxmi Varma

  DOI：10.1016/j.tetlet.2008.01.082

  日期：2008.3

  Calix [4]bis(spirodienones) can perform as either 4 pi or 2 pi components in cycloaddition reactions with various carbo- and heterodienophiles and with 1,2-benzoquinones leading to the formation of highly functionalized macrocycles. In this Letter we report, highly regio- and stereoselective 1,3-dipolar cycloaddition reactions of a bis(spirodienone) derivative of calix[4]arene with nitrones that provide easy access to isoxazolidine derived macrocycles in excellent yields. These isoxazolidine derivatives can be considered as direct precursors of 1,3-amino alcohols. (c) 2008 Elsevier Ltd. All rights reserved.