2-(Isopropylsulfonyl)benzonitrile | 918810-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(Isopropylsulfonyl)benzonitrile
• 英文别名: 2-propan-2-ylsulfonylbenzonitrile
• CAS: 918810-42-1
• 化学式: C₁₀H₁₁NO₂S
• 分子量: 209.27
• InChiKey: JKLDHMJNEOXKCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  66.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(Isopropylsulfonyl)benzonitrile 、 盐酸 在 钯 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以to provide Intermediate 14 (135 mg, 98%)的产率得到2-(isopropylsulfonyl)benzylamine hydrochloride salt
  参考文献：
  名称：

  Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants

  摘要：

  本发明提供了新型的苯基甘氨酰衍生物，其化学式为（I）或（IV）：或其立体异构体、互变异构体、药学上可接受的盐、溶剂化合物或前药，其中变量W、W1、Y、Z、R7、R8、R9和R11如定义所述。这些化合物是七号因子活化酶的选择性抑制剂，可用作药物。

  公开号：

  US20070003539A1

文献信息

• Substituted pyrazoles as p38 kinase inhibitors
  申请人：Naraian S. Ashok

  公开号：US20070078146A1

  公开（公告）日：2007-04-05

  A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R 1 , R 2 , R 3 and R 4 are as described in the specification.

  描述了一类吡唑衍生物，用于治疗p38激酶介导的疾病。特别感兴趣的化合物由公式IA定义，其中R1、R2、R3和R4如规范中所述。
• OXIME COMPOUNDS AND THE USE THEREOF
  申请人：Matsumura Akira

  公开号：US20090298878A1

  公开（公告）日：2009-12-03

  The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO 2 , CR 3 R 4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R 3 and R 4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及式(I)的肟化合物及其药学上可接受的盐、前药或溶剂，其中X为氢、可选取代芳基、可选取代杂环基或类似物；Y为CO、SO2、CR3R4或类似物；Z为可选取代的低烷基、可选取代的芳基或类似物；W为可选取代的低烷基或可选取代的低烯基，R3和R4各自独立地为氢、低烷基或类似物；p为0、1或2，q为0、1或2。本发明还涉及使用式(I)的化合物来治疗、预防或改善对钙通道封锁有反应的疾病，特别是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• ACRYLAMIDE COMPOUNDS AND THE USE THEREOF
  申请人：Mikamiyama Hidenori

  公开号：US20120022069A1

  公开（公告）日：2012-01-26

  The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及以下式子I的丙烯酰胺化合物。本发明还涉及使用式I的化合物来治疗或预防对钙通道阻滞有反应的疾病，尤其是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• Substrate selective inhibitors of insulin-degrading enzyme (IDE) and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US11040976B2

  公开（公告）日：2021-06-22

  Provided herein are compounds of Formulae (RL), (I), (II), (III), (IV), and (V), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, prodrugs, and isotopically labeled derivatives thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of metabolic disorders (e.g., diabetes, hyperglycemia, impaired glucose tolerance, insulin resistance, obesity). The compound are useful as substrate selective inhibitors of insulin-degrading enzyme (IDE).

  本文提供了式(RL)、(I)、(II)、(III)、(IV)和(V)化合物及其药学上可接受的盐、溶液剂、水合物、多晶型、共晶体、同分异构体、立体异构体、原药和同位素标记的衍生物。还提供了涉及本发明化合物的药物组合物、试剂盒和方法，用于治疗代谢紊乱（如糖尿病、高血糖、糖耐量受损、胰岛素抵抗、肥胖）。本发明化合物可作为胰岛素降解酶（IDE）的底物选择性抑制剂。
• PHENYLGLYCINAMIDE AND PYRIDYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1910298A2

  公开（公告）日：2008-04-16