5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-[7-(dimethylamino)heptanoyl]-1,2-dihydro-3H-benzo[e]indole | 1017279-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-[7-(dimethylamino)heptanoyl]-1,2-dihydro-3H-benzo[e]indole
• 英文别名: tert-butyl N-[1-(chloromethyl)-3-[7-(dimethylamino)heptanoyl]-1,2-dihydrobenzo[e]indol-5-yl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate
• CAS: 1017279-29-6
• 化学式: C₃₂H₄₆ClN₃O₅
• 分子量: 588.187
• InChiKey: SOAOMSLKOIAWAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  41
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(bromomethyl)-1-methyl-5-(methylsulfonyl)pyrrole 、 5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-[7-(dimethylamino)heptanoyl]-1,2-dihydro-3H-benzo[e]indole 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以91%的产率得到7-[5-[bis(tert-butoxycarbonyl)amino]-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl]-N,N-dimethyl-N-{[1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl]methyl}-7-oxo-1-heptane ammonium bromide
  参考文献：
  名称：

  Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships

  摘要：

  Quaternary salt analogues based on the DNA minor groove binder and adenine N3 alkylating agent 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole (aminoCBI) show remarkable effects on the body weight of mice (a long-term failure to gain weight relative to matched controls with no loss of appetite or perceptible deterioration in health) following administration of a single (non-toxic) dose between about 0.5-5 mu mol/kg. The nature of the quaternizing group was not important, but a related hydroxyCBI analogue was much less effective. Compounds where the chloro group was replaced by a hydrogen or hydroxy group (thus abrogating DNA alkylating capability) showed no weight control activity. It is speculated, based on other studies, that the marked long-term weight control effect is due to inhibition of bile flow into the intestine and reduced absorption of triglycerides, together with accelerated cell death in spleen and white adipose tissues due to drug accumulation there. This class of compound may serve as interesting tools for further study of these phenomena. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.007
• 作为产物：
  描述：

  5-[allyl(tert-butyloxycarbonyl)amino]-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole 在 盐酸 、 4-二甲氨基吡啶 、 四(三苯基膦)钯 、 camphor-10-sulfonic acid 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 sodium benzenesulfonate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 34.5h， 生成 5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-[7-(dimethylamino)heptanoyl]-1,2-dihydro-3H-benzo[e]indole
  参考文献：
  名称：

  Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships

  摘要：

  Quaternary salt analogues based on the DNA minor groove binder and adenine N3 alkylating agent 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole (aminoCBI) show remarkable effects on the body weight of mice (a long-term failure to gain weight relative to matched controls with no loss of appetite or perceptible deterioration in health) following administration of a single (non-toxic) dose between about 0.5-5 mu mol/kg. The nature of the quaternizing group was not important, but a related hydroxyCBI analogue was much less effective. Compounds where the chloro group was replaced by a hydrogen or hydroxy group (thus abrogating DNA alkylating capability) showed no weight control activity. It is speculated, based on other studies, that the marked long-term weight control effect is due to inhibition of bile flow into the intestine and reduced absorption of triglycerides, together with accelerated cell death in spleen and white adipose tissues due to drug accumulation there. This class of compound may serve as interesting tools for further study of these phenomena. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.007