methoxymethyloxy acetyl chloride | 50918-09-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: methoxymethyloxy acetyl chloride
• 英文别名: 2-(Methoxymethoxy)acetyl chloride
• CAS: 50918-09-7
• 化学式: C₄H₇ClO₃
• 分子量: 138.551
• InChiKey: FVDPDYYUFNKWRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 methoxymethyloxy acetyl chloride 在 三乙胺 作用下， 生成 1-chloro-3-methoxymethoxy-propan-2-one
  参考文献：
  名称：

  Cephalosporin compounds

  摘要：

  通过α-氨基-磷酸酯酯制备新型7-偶氮基-3-头孢烯化合物。这些头孢烯化合物是制备新型和已知有用的抗生素头霉素的中间体。

  公开号：

  US03962224A1
• 作为产物：
  描述：

  2-(甲氧基甲氧基)乙酸乙酯 在 氢氧化钾 、 草酰氯 作用下， 生成 methoxymethyloxy acetyl chloride
  参考文献：
  名称：

  Asymmetric construction of two contiguous stereocenters by diastereoface differentiating addition reaction of thiols to chiral imides: Formal synthesis of (+)-diltiazem

  摘要：

  A high degree of diastereoselectivity has been achieved on the asymmetric construction of two contiguous stereocenters by the conjugate addition of thiols to alpha,beta-unsaturated imides possessing Evans's chiral auxiliary. Addition reactions of thiophenol to chiral E- and Z-2-methylcrotonyl imides 4 proceeded with high diastereoface selectivities. Diastereoselectivities were discussed when E- and Z-imides 4 and 5 were used as the substrates. A successful application was demonstrated by the formal synthesis of a clinically useful cardiac drug, (+)-diltiazem. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(96)01191-x

文献信息

• Cephalosporin compounds
  申请人：Merck & Co., Inc.

  公开号：US03962224A1

  公开（公告）日：1976-06-08

  Novel 7-azido-3-cephem compounds are prepared via .alpha.-amino-phosphonoacetate esters. The cephem compounds are intermediates for the preparation of novel and known useful antibiotic cephalosporins.

  通过α-氨基-磷酸酯酯制备新型7-偶氮基-3-头孢烯化合物。这些头孢烯化合物是制备新型和已知有用的抗生素头霉素的中间体。
• Asymmetric construction of two contiguous stereocenters by diastereoface differentiating addition reaction of thiols to chiral imides: Formal synthesis of (+)-diltiazem
  作者：Okiko Miyata、Tetsuro Shinada、Ichiya Ninomiya、Takeaki Naito

  DOI：10.1016/s0040-4020(96)01191-x

  日期：1997.2

  A high degree of diastereoselectivity has been achieved on the asymmetric construction of two contiguous stereocenters by the conjugate addition of thiols to alpha,beta-unsaturated imides possessing Evans's chiral auxiliary. Addition reactions of thiophenol to chiral E- and Z-2-methylcrotonyl imides 4 proceeded with high diastereoface selectivities. Diastereoselectivities were discussed when E- and Z-imides 4 and 5 were used as the substrates. A successful application was demonstrated by the formal synthesis of a clinically useful cardiac drug, (+)-diltiazem. (C) 1997, Elsevier Science Ltd.