N-benzyl trifluoromethanesulfenamide | 1045821-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl trifluoromethanesulfenamide
• 英文别名: 1-phenyl-N-[(trifluoromethyl)thio]methanamine；1-phenyl-N-(trifluoromethylsulfanyl)methanamine
• CAS: 1045821-54-2
• 化学式: C₈H₈F₃NS
• 分子量: 207.219
• InChiKey: FDKWRGJBTPPFJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(三氟甲硫基)邻苯二甲酰亚胺 、 苄胺 以66%的产率得到N-benzyl trifluoromethanesulfenamide
  参考文献：
  名称：

  使用货架稳定的亲电子SCF3试剂选择性和可扩展地合成三氟甲烷亚磺酰胺和氟化的不对称二硫化物

  摘要：

  描述了在无金属的温和条件下使用N-（三氟甲硫基）邻苯二甲酰亚胺对氮亲核试剂和硫醇的化学选择性三氟甲硫基化反应。由相应的脂族和芳族胺和硫醇以高收率制备了一系列三氟甲亚磺酰胺和不对称二硫化物。反应操作简单，可耐受多种官能团。三氟甲亚磺酰胺和二硫化物属于有趣的有机分子类别，在医药和农业化学应用中均具有非凡的性能。

  DOI：

  10.1002/chem.201405654

文献信息

• [EN] AUTOTAXIN INHIBITORS<br/>[FR] INHIBITEURS DE L'AUTOTAXINE
  申请人：MERCK PATENT GMBH

  公开号：WO2010112124A1

  公开（公告）日：2010-10-07

  The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

  本发明涉及按照式(I)的化合物作为自体脂肪酶抑制剂，以及利用这种化合物治疗和/或预防由增加的溶酶磷脂酸水平和/或自体脂肪酶的激活引起、介导和/或传播的生理和/或病理条件，特别是不同癌症的治疗。
• AUTOTAXIN INHIBITORS
  申请人：Schultz Melanie

  公开号：US20120015976A1

  公开（公告）日：2012-01-19

  The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

  本发明涉及公式（I）的化合物，作为自体税脂酰酰肽酶抑制剂，并且利用这种化合物治疗和/或预防由升高的溶解磷脂酸水平和/或自体税脂酰酰肽酶的激活引起、介导和/或传播的生理和/或病理生理状况，特别是不同癌症。
• Resist composition and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US10222696B2

  公开（公告）日：2019-03-05

  A resist composition comprising a base polymer and a biguanide salt compound offers a high dissolution contrast, minimal LWR, and dimensional stability on PPD.

  由基质聚合物和双胍盐化合物组成的抗蚀剂组合物在 PPD 上具有较高的溶解对比度、最小的 LWR 和尺寸稳定性。
• Synthesis of Trifluoromethanesulfinamidines and -sulfanylamides
  作者：Aurélien Ferry、Thierry Billard、Bernard R. Langlois、Eric Bacqué

  DOI：10.1021/jo8018544

  日期：2008.12.5

  Fluorinated moieties constitute important substituents used in many applications to modify the properties of molecules. The action of DAST onto Ruppert's rea gent yields to a not isolable intermediate that can then react with various primary amines to give trifluoromethanesulfinamidines and trifluoromethanesulfanylamides. Such compounds were unknown until now and constitute interesting new families of fluorinated molecules.
• PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS
  申请人：Schiemann Kai

  公开号：US20120059016A1

  公开（公告）日：2012-03-08

  The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.