{4-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-piperidin-1-yl}-(4-methyl-2-cyclopropyl-pyrimidin-5-yl)-methanone | 1097880-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {4-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-piperidin-1-yl}-(4-methyl-2-cyclopropyl-pyrimidin-5-yl)-methanone
• 英文别名: [4-[(1R)-1-amino-2-(2,4,5-trifluorophenyl)ethyl]piperidin-1-yl]-(2-cyclopropyl-4-methylpyrimidin-5-yl)methanone
• CAS: 1097880-18-6
• 化学式: C₂₂H₂₅F₃N₄O
• 分子量: 418.462
• InChiKey: NXHLIEWUMFCMSB-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  [(R)-1-[1-(2-Cyclopropyl-4-methyl-pyrimidine-5-carbonyl)-piperidin-4-yl]-2-(2,4,5-trifluorophenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 在 二乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 {4-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-piperidin-1-yl}-(4-methyl-2-cyclopropyl-pyrimidin-5-yl)-methanone
  参考文献：
  名称：

  Dpp-IV inhibitors

  摘要：

  本发明涉及式（I）化合物，其中R1、R2、R3和n的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。本发明还涉及制备这种化合物以及将其作为药物的生产和使用。

  公开号：

  EP2019099A1

文献信息

• [EN] DPP-IV INHIBITORS<br/>[FR] INHIBITEURS DE DPP-IV
  申请人：SANTHERA PHARMACEUTICALS CH

  公开号：WO2009003681A1

  公开（公告）日：2009-01-08

  The invention relates to compounds of formula (I) wherein R1, R2, R3 and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.
• Dpp-IV inhibitors
  申请人：Santhera Pharmaceuticals (Schweiz) AG

  公开号：EP2019099A1

  公开（公告）日：2009-01-28

  The invention relates to compounds of formula (I) wherein R1, R2, R3 and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereof as medicament.

  本发明涉及式（I）化合物，其中R1、R2、R3和n的含义如描述和权利要求中所述。所述化合物可用作DPP-IV抑制剂。本发明还涉及制备这种化合物以及将其作为药物的生产和使用。