(2S,5S)-5-phenyl-1-[(1S)-1-phenyl-2-trimethylsilyloxyethyl]pyrrolidine-2-carbonitrile | 1071227-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2S,5S)-5-phenyl-1-[(1S)-1-phenyl-2-trimethylsilyloxyethyl]pyrrolidine-2-carbonitrile
• CAS: 1071227-09-2
• 化学式: C₂₂H₂₈N₂OSi
• 分子量: 364.563
• InChiKey: HAJBDTZCRYMFJT-FDFHNCONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.31
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 (3S,5S,7aR)-3,5-diphenylhexahydropyrrolo<2,1-b><1,3>oxazole 生成 (2S,5S)-5-phenyl-1-[(1S)-1-phenyl-2-trimethylsilyloxyethyl]pyrrolidine-2-carbonitrile 、
  参考文献：
  名称：

  Short Enantioselective Syntheses of trans-5-Alkylprolines from New Functionalized Amino Alcohols

  摘要：

  GraphicsAmino alcohols, having an enol ether function, cyclized in acidic medium to give quantitatively diastereosomerically pure bicyclic compounds that were transformed in five steps in enantiopure trans-5-alkylproline derivatives.

  DOI：

  10.1021/jo8014243

文献信息

• Short Enantioselective Syntheses of <i>trans</i>-5-Alkylprolines from New Functionalized Amino Alcohols
  作者：Jeanne Alladoum、Sylvain Roland、Emmanuel Vrancken、Pierre Mangeney、Catherine Kadouri-Puchot

  DOI：10.1021/jo8014243

  日期：2008.12.19

  GraphicsAmino alcohols, having an enol ether function, cyclized in acidic medium to give quantitatively diastereosomerically pure bicyclic compounds that were transformed in five steps in enantiopure trans-5-alkylproline derivatives.